Dröge W, Schmidt H, Nick S, Sonsky B
Immunopharmacology. 1986 Feb;11(1):1-6. doi: 10.1016/0162-3109(86)90058-5.
Histamine (0.5 g/kg) was found to augment the activation of cytotoxic T lymphocytes in vivo, if injected in the late phase (day 4) of the response. The production of interleukin-2 in concanavalin A-activated spleen cell cultures was also strongly augmented by 1 X 10(-2) M histamine or by a combination of 2 X 10(-3) M histamine and histaminase (diamine oxidase). This suggests the possibility that the augmentation in vivo is mediated by the oxidized histamine derivative imidazolylacetaldehyde, since diamine oxidase occurs in many tissues. The interleukin-2-dependent proliferation of a T cell clone, on the other hand, was not affected by histamine with or without diamine oxidase. The experiments suggest that histamine supports the late phase of the cytotoxic T lymphocyte response by augmenting the interleukin-2 production.
研究发现，如果在反应后期（第4天）注射组胺（0.5克/千克），可增强体内细胞毒性T淋巴细胞的激活。在伴刀豆球蛋白A激活的脾细胞培养物中，1×10⁻²M组胺或2×10⁻³M组胺与组胺酶（二胺氧化酶）的组合也能强烈增强白细胞介素-2的产生。这表明体内增强作用可能是由氧化型组胺衍生物咪唑基乙醛介导的，因为二胺氧化酶存在于许多组织中。另一方面，T细胞克隆的白细胞介素-2依赖性增殖不受有无二胺氧化酶的组胺影响。这些实验表明，组胺通过增强白细胞介素-2的产生来支持细胞毒性T淋巴细胞反应的后期阶段。
