Tommasi Marco, Sergi Maria Rita, Konstantinidou Fani, Franzago Marica, Pesce Mirko, Fratta Irene La, Grilli Alfredo, Stuppia Liborio, Picconi Laura, Saggino Aristide, Gatta Valentina
Department of Medicine and Aging Sciences, "G. d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
Department of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, "G. d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
Front Biosci (Landmark Ed). 2021 Nov 30;26(11):1064-1074. doi: 10.52586/5009.
: The real impact of genetic factors on personality is still unknown, even if in literature about 50% of variance in personality traits are considered genetically determined. The determination of the genetic variance in personality traits could promote psychological well-being and the prevention of psychopathologies, because there are many experimental evidences showing that mental illness is associated to personality. Numerous studies have showed that Catechol-O-methyltransferase (), brain derived neurotrophic factor () and serotonin transporter () are genes whose variants are associated with personality traits. This aim of this study is the investigation of the association between personality traits and /rs25531 promoter variant, Val158Met and Val66Met gene polymorphisms. : The sample was composed by 132 healthy female students. Genomic DNA was extracted from buccal swab, while personality was assessed with Cloninger's Temperament and Character Inventory-Revised (TCI-R). Linear discriminant analysis was used to analyze how personality characteristics can differentiate individuals in relation to their genetic polymorphisms. : Data showed that the temperament trait Reward Dependence discriminated individuals with different variants; Novelty Seeking and Harm Avoidance discriminated individuals with different variants; Persistence discriminated individuals with different variants. : Since these traits are connected to psychological diseases as depression, social anxiety, anorexia and obsessive-compulsive disorders of personality, the study of their genetic component can be used as intermediary issue to better define the connection between genes and predisposition toward maladaptive behavior and mental illness.
遗传因素对人格的实际影响仍然未知，尽管在文献中约50%的人格特质差异被认为是由基因决定的。确定人格特质的遗传差异有助于促进心理健康和预防精神疾病，因为有许多实验证据表明精神疾病与人格有关。大量研究表明，儿茶酚-O-甲基转移酶（）、脑源性神经营养因子（）和5-羟色胺转运体（）的基因变体与人格特质相关。本研究的目的是调查人格特质与/rs25531启动子变体、Val158Met和Val66Met基因多态性之间的关联。：样本由132名健康女学生组成。从口腔拭子中提取基因组DNA，同时用克隆宁格的气质与性格量表修订版（TCI-R）评估人格。采用线性判别分析来分析人格特征如何根据个体的基因多态性进行区分。：数据显示，气质特质奖励依赖能区分具有不同变体的个体；新奇寻求和回避伤害能区分具有不同变体的个体；坚持性能区分具有不同变体的个体。：由于这些特质与抑郁症、社交焦虑症、厌食症和强迫性人格障碍等心理疾病有关，对其遗传成分的研究可作为一个中间问题，以更好地界定基因与适应不良行为及精神疾病易感性之间的联系。
