从自然设计中学习局部麻醉药物传递。

Learning from natural design for local anesthetic delivery.

机构信息

Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, 11 Zhongguancun Beiyitiao, Beijing 100190, China; Sino-Danish Center for Education and Research, Sino-Danish College, University of the Chinese Academy of Sciences, Beijing 100049, China.

出版信息

Trends Pharmacol Sci. 2022 Feb;43(2):81-83. doi: 10.1016/j.tips.2021.11.012. Epub 2021 Nov 29.

DOI:10.1016/j.tips.2021.11.012

PMID:34857408

Abstract

There is a sizeable but unfilled need for drug delivery systems that prolong the duration of action and reduce the systemic toxicity of local anesthetics. Inspired by the interactions of anesthetics with their natural binding sites on sodium channels, Ji et al. designed self-assembled nanostructures that achieve specific delivery and sustained release of anesthetics.

摘要

对于能够延长局麻药作用时间和降低全身毒性的药物输送系统，存在着相当大但尚未得到满足的需求。受局麻药与钠离子通道上天然结合位点相互作用的启发，Ji 等人设计了自组装纳米结构，以实现对麻醉剂的特异性输送和持续释放。