Rocio Soledad Garcia-Lazaro, Lorena Gisel Caligiuri, Norailys Lorenzo, Humberto Lamdan, Daniel Fernando Alonso, Hernan Gabriel Farina
Molecular and Translational Oncology Center, Science and Technology Department, National University of Quilmes, Buenos Aires, Argentina.
Front Pharmacol. 2021 Nov 11;12:750197. doi: 10.3389/fphar.2021.750197. eCollection 2021.
Breast cancer (BC) is the most frequent cancer in women and tumor metastasis is a major cause of cancer-related deaths. Our aim was to evaluate anti-metastatic properties of yerba mate extract (YMe) in BC models. 4T1, F3II, MCF-7, and MDA-MB231 cell lines were used to perform assays. The F3II syngeneic mammary carcinoma model in BALB/c mice was used to evaluate tumor progression, BC metastasis and survival. Cells were inoculated subcutaneously into the flank for the heterotopic model and into the mammary fat pad for the orthotopic model. YMe was administered p.o. in a dose of 1.6 g/kg/day. YMe inhibited cell proliferation and reduced tumor cell adhesion, migration and invasion. These biological effects were cell-line dependent. YMe reduced tumor metastasis and increased mice survival in both models. Our preclinical results suggest that YMe could modulate tumor progression and metastasis in BC models.
乳腺癌（BC）是女性中最常见的癌症，肿瘤转移是癌症相关死亡的主要原因。我们的目的是评估马黛茶提取物（YMe）在乳腺癌模型中的抗转移特性。使用4T1、F3II、MCF-7和MDA-MB231细胞系进行实验。采用BALB/c小鼠中的F3II同基因乳腺癌模型评估肿瘤进展、乳腺癌转移和生存率。将细胞皮下接种到侧腹用于异位模型，接种到乳腺脂肪垫用于原位模型。YMe以1.6 g/kg/天的剂量口服给药。YMe抑制细胞增殖，并降低肿瘤细胞的黏附、迁移和侵袭。这些生物学效应依赖于细胞系。YMe在两种模型中均减少了肿瘤转移并提高了小鼠生存率。我们的临床前结果表明，YMe可调节乳腺癌模型中的肿瘤进展和转移。
