Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, United States.
The Integrated Biomedical Sciences (IBMS) Graduate Program, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, United States.
Front Immunol. 2021 Nov 11;12:765349. doi: 10.3389/fimmu.2021.765349. eCollection 2021.
The development of vaccines against infectious diseases has helped us battle the greatest threat to public health. With the emergence of novel viruses, targeted immunotherapeutics ranging from informed vaccine development to personalized medicine may be the very thing that separates us between life and death. Late in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), made a remarkable entrance to human civilization, being one of many to cross the species barrier. This review discusses the important aspects of COVID-19, providing a brief overview of our current understanding of dysregulated immune responses developed using various experimental models, a brief outline of experimental models of COVID-19 and more importantly, the rapid development of vaccines against COVID-19.
针对传染病的疫苗的发展帮助我们对抗了对公共健康的最大威胁。随着新型病毒的出现，从知情疫苗开发到个性化医疗的靶向免疫疗法可能是将我们与生死分开的关键。2019 年末，严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2），即 2019 年冠状病毒病（COVID-19）的病原体，以一种显著的方式进入人类文明，是许多跨越物种屏障的病毒之一。这篇综述讨论了 COVID-19 的重要方面，简要概述了我们目前对使用各种实验模型开发的失调免疫反应的理解，简要概述了 COVID-19 的实验模型，更重要的是，快速开发了针对 COVID-19 的疫苗。
