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The Advisory Committee on Immunization Practices' Interim Recommendation for Use of Moderna COVID-19 Vaccine - United States, December 2020.美国免疫实施咨询委员会对使用 Moderna COVID-19 疫苗的临时建议-2020 年 12 月。
MMWR Morb Mortal Wkly Rep. 2021 Jan 1;69(5152):1653-1656. doi: 10.15585/mmwr.mm695152e1.
2
Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic.评估 COVID-19 大流行期间孕妇的母婴 SARS-CoV-2 病毒载量、胎盘抗体转移和胎盘病理学。
JAMA Netw Open. 2020 Dec 1;3(12):e2030455. doi: 10.1001/jamanetworkopen.2020.30455.
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Effectiveness of Vaccination During Pregnancy to Prevent Infant Pertussis.孕期接种疫苗预防婴儿百日咳的有效性。
Pediatrics. 2017 May;139(5). doi: 10.1542/peds.2016-4091. Epub 2017 Apr 3.
4
Infant outcomes after exposure to Tdap vaccine in pregnancy: an observational study.孕期接种破伤风类毒素、白喉、百日咳（Tdap）疫苗后的婴儿结局：一项观察性研究。
BMJ Open. 2016 Jan 6;6(1):e009536. doi: 10.1136/bmjopen-2015-009536.
5
Immune responses in infants whose mothers received Tdap vaccine during pregnancy.孕妇在孕期接种 Tdap 疫苗对婴儿的免疫应答。
Pediatr Infect Dis J. 2013 Nov;32(11):1257-60. doi: 10.1097/INF.0b013e3182a09b6a.
6
Differential sensitivities of severe acute respiratory syndrome (SARS) coronavirus spike polypeptide enzyme-linked immunosorbent assay (ELISA) and SARS coronavirus nucleocapsid protein ELISA for serodiagnosis of SARS coronavirus pneumonia.严重急性呼吸综合征（SARS）冠状病毒刺突多肽酶联免疫吸附测定（ELISA）和SARS冠状病毒核衣壳蛋白ELISA在SARS冠状病毒肺炎血清学诊断中的差异敏感性。
J Clin Microbiol. 2005 Jul;43(7):3054-8. doi: 10.1128/JCM.43.7.3054-3058.2005.
7
Effectiveness of influenza vaccine during pregnancy in preventing hospitalizations and outpatient visits for respiratory illness in pregnant women and their infants.孕期流感疫苗在预防孕妇及其婴儿因呼吸道疾病住院和门诊就诊方面的有效性。
Am J Perinatol. 2004 Aug;21(6):333-9. doi: 10.1055/s-2004-831888.

产妇接种疫苗后脐血中检测到针对 SARS-CoV-2 的新生儿抗体——病例报告。

Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination - a case report.

机构信息

Florida Atlantic University - Charles E. Schmidt College of Medicine, 777 Glades Road BC-71, Boca Raton, FL, 33431, USA.

, Boca Raton, USA.

出版信息

BMC Pediatr. 2021 Mar 22;21(1):138. doi: 10.1186/s12887-021-02618-y.

DOI:10.1186/s12887-021-02618-y
PMID:33752624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7982334/
Abstract

BACKGROUND

Maternal vaccination for Influenza and Tetanus, Diphtheria, acellular Pertussis (TDaP) have been well studied in terms of safety and efficacy for protection of the newborn by placental passage of antibodies. Similar newborn protection would be expected after maternal vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). There is a significant and urgent need for research regarding safety and efficacy of vaccination against SARS-CoV-2 during pregnancy.

CASE PRESENTATION

A vigorous, healthy, full-term female was born to a COVID-19 naïve mother who had received a single dose of messenger RNA (mRNA) vaccine for SARS-CoV-2 3 weeks prior to delivery. IgG cord blood antibodies were detected to SARS-CoV-2 at the time of birth.

CONCLUSION

Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.

摘要

背景

母体接种流感疫苗和破伤风、白喉、无细胞百日咳（Tdap）在通过胎盘传递抗体来保护新生儿方面的安全性和有效性已得到充分研究。母体接种严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）疫苗后，预计也会对新生儿产生类似的保护作用，SARS-CoV-2 是导致 2019 年冠状病毒病（COVID-19）的病毒。迫切需要对 COVID-19 大流行期间孕妇接种 SARS-CoV-2 疫苗的安全性和有效性进行研究。

病例介绍

一位健康、足月的女婴出生，其母亲在分娩前 3 周接种了一剂信使 RNA（mRNA）疫苗以预防 SARS-CoV-2。在出生时检测到 SARS-CoV-2 的 IgG 脐血抗体。

结论

在这里，我们报告了首例已知的母亲接种 SARS-CoV-2 疫苗后在脐血中可检测到 SARS-CoV-2 IgG 抗体的婴儿病例。