Fatima Nishat, Baqri Syed Shabihe Raza, Bhattacharya Atrayee, Koney Nii Koney-Kwaku, Husain Kazim, Abbas Ata, Ansari Rais A
Department of Chemistry, Shia Postgraduate College, Lucknow, India.
Department of Zoology, Shia Postgraduate College, Lucknow, India.
Front Genet. 2021 Nov 9;12:758733. doi: 10.3389/fgene.2021.758733. eCollection 2021.
Epigenetic regulation involves reversible changes in histones and DNA modifications that can be inherited without any changes in the DNA sequence. Dysregulation of normal epigenetic processes can lead to aberrant gene expression as observed in many diseases, notably cancer. Recent insights into the mechanisms of DNA methylation, histone modifications, and non-coding RNAs involved in altered gene expression profiles of tumor cells have caused a paradigm shift in the diagnostic and therapeutic approaches towards cancer. There has been a surge in search for compounds that could modulate the altered epigenetic landscape of tumor cells, and to exploit their therapeutic potential against cancers. Flavonoids are naturally occurring phenol compounds which are abundantly found among phytochemicals and have potentials to modulate epigenetic processes. Knowledge of the precise flavonoid-mediated epigenetic alterations is needed for the development of epigenetics drugs and combinatorial therapeutic approaches against cancers. This review is aimed to comprehensively explore the epigenetic modulations of flavonoids and their anti-tumor activities.
表观遗传调控涉及组蛋白和DNA修饰的可逆变化，这些变化可以在DNA序列无任何改变的情况下遗传。正常表观遗传过程的失调会导致基因表达异常，这在许多疾病中都有观察到，尤其是癌症。最近对参与肿瘤细胞基因表达谱改变的DNA甲基化、组蛋白修饰和非编码RNA机制的深入了解，引发了癌症诊断和治疗方法的范式转变。寻找能够调节肿瘤细胞表观遗传格局改变的化合物，并开发其抗癌治疗潜力的研究激增。黄酮类化合物是天然存在的酚类化合物，在植物化学物质中大量存在，具有调节表观遗传过程的潜力。开发针对癌症的表观遗传学药物和联合治疗方法需要了解黄酮类化合物介导的精确表观遗传改变。本综述旨在全面探讨黄酮类化合物的表观遗传调控及其抗肿瘤活性。
