Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran.
Student Research Committee.
Eur J Cancer Prev. 2021 Sep 1;30(5):413-421. doi: 10.1097/CEJ.0000000000000645.
Flavonoids, a broad class of polyphenolic compounds, can potentially have several therapeutic properties in human diseases, including protective effects against oxidative stress, inflammation, cardiovascular disease, diabetes, neurodegenerative disorders, and cancers. Luteolin as a member of flavonoids has been found to exhibit several anticancer properties mainly through cell apoptosis induction, inhibition of invasion, cell proliferation, network formation, and migration. Recent studies have revealed that phytochemicals such as luteolin may exert therapeutic properties through microRNAs (miRNAs or miRs), which have been emerged as important molecules in cancer biology in recent years. miRNAs, as a class of noncoding RNAs, have several important roles in cancer progression or regression. In this review, we aimed to summarize and discuss the role of miRNAs in the luteolin effects on different cancers. This review can be in line with the studies, which have shown that miRNAs may be potential therapeutic targets in cancer treatment.
类黄酮是一大类多酚化合物，可能对人类疾病具有多种治疗特性，包括对氧化应激、炎症、心血管疾病、糖尿病、神经退行性疾病和癌症的保护作用。作为类黄酮的一员，木樨草素已被发现具有多种抗癌特性，主要通过细胞凋亡诱导、抑制侵袭、细胞增殖、网络形成和迁移来实现。最近的研究表明，植物化学物质，如木樨草素，可能通过 microRNAs（miRNAs 或 miRs）发挥治疗作用，近年来，miRNAs 已成为癌症生物学中的重要分子。miRNAs 作为一类非编码 RNA，在癌症的进展或消退中具有几个重要作用。在这篇综述中，我们旨在总结和讨论 miRNAs 在木樨草素对不同癌症影响中的作用。这篇综述与研究一致，表明 miRNAs 可能是癌症治疗中潜在的治疗靶点。
