需要与乳腺癌相鉴别的IgG4相关性乳腺炎：一例报告

IgG4-related mastitis requiring differentiation from breast cancer: a case report.

作者信息

Asano Yuka, Kashiwagi Shinichiro, Kawano Yuko, Tanaka Sayaka, Kuwae Yuko, Takashima Tsutomu, Ohsawa Masahiko, Hirakawa Kosei, Ohira Masaichi

机构信息

Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.

Department of Diagnostic Pathology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.

出版信息

J Surg Case Rep. 2021 Nov 29;2021(11):rjaa240. doi: 10.1093/jscr/rjaa240. eCollection 2021 Nov.

DOI:10.1093/jscr/rjaa240

PMID:34858570

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8634083/

Abstract

Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a group of chronic relapsing inflammatory conditions. Although IgG4-RD can occur in various organs, it is rarely observed in mammary glands. Here, we report a case of IgG4-related mastitis (IgG4-RM) that needed to be differentiated from breast cancer. A 54-year-old woman was examined for a tumor in her left breast. Mammary ultrasonography revealed an irregular hypoechoic tumor measuring 45.0 × 43.0 × 32.0 mm in size. A core-needle biopsy of the left breast tissue revealed a high degree of mixed T and B lymphocytic and plasma cell infiltration, as well as interstitial fibrosis. IgG4-RD was diagnosed based on hematological examination that revealed an abnormal IgG4 value of 332 mg/dl. All the clinical diagnostic criteria for IgG4 were met, resulting in a definitive diagnosis of IgG4-RM.

摘要

免疫球蛋白（Ig）G4相关疾病（IgG4-RD）是一组慢性复发性炎症性疾病。尽管IgG4-RD可发生于多个器官，但在乳腺中很少见。在此，我们报告一例需要与乳腺癌相鉴别的IgG4相关性乳腺炎（IgG4-RM）病例。一名54岁女性因左侧乳腺肿瘤接受检查。乳腺超声检查发现一个不规则低回声肿瘤，大小为45.0×43.0×32.0mm。对左侧乳腺组织进行粗针活检显示有高度混合的T和B淋巴细胞及浆细胞浸润，以及间质纤维化。基于血液学检查显示IgG4值异常为332mg/dl，诊断为IgG4-RD。所有IgG4的临床诊断标准均符合，最终确诊为IgG4-RM。