Li Wenjie, Miao Yinping, Guo Tuan, Zhang Kialiang, Yao Jianquan
Tianjin Key Laboratory of Film Electronic and Communicate Devices, School of Integrated Circuit Science and Engineering, Tianjin University of Technology, Tianjin 300384, China.
Institute of Photonics Technology, Jinan University, Guangzhou 510632, China.
Biomed Opt Express. 2021 Oct 22;12(11):7051-7063. doi: 10.1364/BOE.442602. eCollection 2021 Nov 1.
An optofluidic system based on photothermal spectroscopy is proposed, which combines molecular photothermal effect with NbCT MXene-tilted fiber Bragg grating (TFBG) for the detection of organophosphorus pesticides (OPs) with temperature compensated. Under the irradiation of excitation light, the photothermal effect of OPs produces a detectable change in the refractive index of the sample, and the concentration of chlorpyrifos can be quantified using TFBG. The NbCT MXene coated TFBG allow more molecules to be absorbed on the surface of TFBG, which enhances the interaction between light and matter, and improves the sensitivity of detection. The temperature compensation is performed by referring to the core mode of TFBG, thereby eliminating the influence of ambient temperature on the photothermal detection. The experimental results show that the sensitivity reaches 1.8 pm/ppm with a limit of detection (LOD) of 0.35 ppm, and the obtained temperature compensation coefficient is 4.84 ppm/°C. This photothermal biosensor has the advantages of low LOD, temperature compensation and real-time online monitoring, making it a good candidate in medicine, chemistry and environmental monitoring.
提出了一种基于光热光谱的光流控系统，该系统将分子光热效应与NbCT MXene倾斜光纤布拉格光栅（TFBG）相结合，用于温度补偿下有机磷农药（OPs）的检测。在激发光照射下，OPs的光热效应使样品的折射率产生可检测的变化，毒死蜱的浓度可通过TFBG进行定量。涂覆有NbCT MXene的TFBG使更多分子吸附在TFBG表面，增强了光与物质之间的相互作用，提高了检测灵敏度。通过参考TFBG的芯模进行温度补偿，从而消除环境温度对光热检测的影响。实验结果表明，灵敏度达到1.8 pm/ppm，检测限（LOD）为0.35 ppm，获得的温度补偿系数为4.84 ppm/°C。这种光热生物传感器具有低检测限、温度补偿和实时在线监测等优点，使其成为医学、化学和环境监测领域的理想候选者。
