QS2/QT 比值作为左心室对自主神经和变力性刺激的适当反应指标。

The QS2/QT ratio as an index of appropriate left ventricular response to autonomic and inotropic stimuli.

作者信息

Cokkinos D V, Rivas A, Perrakis C, Diakoumakos N, De Puey E G, Burdine J A, Leachman R D, Hall R J

出版信息

Acta Cardiol. 1986;41(1):9-21.

Abstract

Dissociation between duration of electrical and mechanical systole has been seen with increase of myocardial shortening velocity or adrenergic activity. We found a decrease of the QS2/QT ratio after exercise in 10 pts with semisitting bicycle maximal exercise test and a normal radionuclide angiogram. No change was seen in 9 patients with a normal study with beta blockade, and in pts with a abnormal radionuclide test, without beta blockade (11 pts). In 19 normal active individuals, a significant QS2/QT decrease (p less than 0.001) was seen after a submaximal exercise treadmill test, which was inhibited by beta blockade. We believe that QS2/QT diminution is suggestive of an increase of the inotropic state of the left ventricle with exercise, produced through adrenergic stimulation. It is not seen either when an ischemic left ventricle cannot adequately respond to exercise or after beta blockade.

摘要

随着心肌缩短速度或肾上腺素能活性的增加，已观察到电收缩期和机械收缩期持续时间之间的分离。我们对10例患者进行半卧位自行车最大运动试验且放射性核素血管造影正常，发现运动后QS2/QT比值降低。9例研究正常且接受β受体阻滞剂治疗的患者以及11例放射性核素检查异常且未接受β受体阻滞剂治疗的患者未见变化。在19名正常活动个体中，次极量运动平板试验后可见显著的QS2/QT降低（p<0.001），这一降低被β受体阻滞剂抑制。我们认为，QS2/QT降低提示运动时左心室收缩力状态增加，这是由肾上腺素能刺激产生的。当缺血性左心室不能对运动充分反应时或在β受体阻滞剂治疗后均未观察到这种情况。