Galigalidou Chrysi, Zaragoza-Infante Laura, Iatrou Anastasia, Chatzidimitriou Anastasia, Stamatopoulos Kostas, Agathangelidis Andreas
Institute of Applied Biosciences (INAB), Centre for Research and Technology Hellas (CERTH), Thessaloniki, Greece.
Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece.
Front Oncol. 2021 Nov 11;11:769612. doi: 10.3389/fonc.2021.769612. eCollection 2021.
The term monoclonal B-cell lymphocytosis (MBL) describes the presence of a clonal B cell population with a count of less than 5 × 10/L and no symptoms or signs of disease. Based on the B cell count, MBL is further classified into 2 distinct subtypes: 'low-count' and 'high-count' MBL. High-count MBL shares a series of biological and clinical features with chronic lymphocytic leukemia (CLL), at least of the indolent type, and evolves to CLL requiring treatment at a rate of 1-2% per year, whereas 'low-count' MBL seems to be distinct, likely representing an immunological rather than a pre-malignant condition. That notwithstanding, both subtypes of MBL can carry 'CLL-specific' genomic aberrations such as cytogenetic abnormalities and gene mutations, yet to a much lesser extent compared to CLL. These findings suggest that such aberrations are mostly relevant for disease progression rather than disease onset, indirectly pointing to microenvironmental drive as a key contributor to the emergence of MBL. Understanding microenvironmental interactions is therefore anticipated to elucidate MBL ontogeny and, most importantly, the relationship between MBL and CLL.
单克隆B淋巴细胞增多症（MBL）这一术语描述的是存在克隆性B细胞群体，其计数小于5×10⁹/L，且无疾病症状或体征。根据B细胞计数，MBL进一步分为两种不同的亚型：“低计数”和“高计数”MBL。高计数MBL与慢性淋巴细胞白血病（CLL），至少是惰性类型的CLL，具有一系列生物学和临床特征，并且以每年1%-2%的速率演变为需要治疗的CLL，而“低计数”MBL似乎有所不同，可能代表一种免疫状态而非癌前状态。尽管如此，MBL的两种亚型都可能携带“CLL特异性”基因组畸变，如细胞遗传学异常和基因突变，但与CLL相比程度要小得多。这些发现表明，此类畸变大多与疾病进展相关而非疾病发生，间接表明微环境驱动是MBL出现的关键因素。因此，了解微环境相互作用有望阐明MBL的发生发展，最重要的是，阐明MBL与CLL之间的关系。
