脂肪基质细胞促进结肠癌细胞向间充质样表型转变。
Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype.
作者信息
Di Franco Simone, Stassi Giorgio
机构信息
Department of Surgical Oncological and Stomatological Sciences (DICHIRONS), University of Palermo, Palermo, Italy.
出版信息
Mol Cell Oncol. 2021 Oct 18;8(5):1986343. doi: 10.1080/23723556.2021.1986343. eCollection 2021.
Abstract
Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.
摘要
结肠癌进展是随着肥胖而增加的风险之一。我们最近揭示了脂肪组织释放的分子HGF和IL-6使结肠直肠癌（CRC）细胞获得间充质特征的分子机制。靶向脂肪源性因子可消除肥胖患者中CRC干细胞（CR-CSCs）的转移潜能。
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