Rehm W S, Carrasquer G, Schwartz M
Am J Physiol. 1986 Apr;250(4 Pt 1):G511-7. doi: 10.1152/ajpgi.1986.250.4.G511.
Thiocyanate (SCN) produced a rapid inhibition of acid secretion and a concurrent rapid increase in the transmucosal potential difference (PD) and resistance. After inhibition, resistance rapidly peaked and then decreased. In contrast, omeprazole produced a slow inhibition of secretion and a slow increase in PD and resistance. The peak increase in resistance with SCN was significantly greater than the steady-state increases for both SCN and omeprazole. All increases were significant. The increases in PD and resistance are greater at high H+ rates than at low H+ rates. We postulate that the peak SCN increase in resistance is due to the increase in resistance of the secretory membrane, which is followed by a decrease in resistance of the nutrient membrane. On this basis the omeprazole increase in resistance that occurs concurrently with the slow decrease in the H+ rate is a result of a concurrent change of the resistances of the two opposing membranes.
硫氰酸盐（SCN）可迅速抑制胃酸分泌，并同时使跨粘膜电位差（PD）和电阻迅速增加。抑制后，电阻迅速达到峰值，然后下降。相比之下，奥美拉唑对胃酸分泌的抑制作用缓慢，对PD和电阻的增加也较为缓慢。SCN引起的电阻峰值增加显著大于SCN和奥美拉唑的稳态增加。所有增加均具有显著性。高H⁺分泌速率时PD和电阻的增加幅度大于低H⁺分泌速率时。我们推测，SCN引起的电阻峰值增加是由于分泌膜电阻增加，随后营养膜电阻降低。在此基础上，与H⁺分泌速率缓慢下降同时发生的奥美拉唑引起的电阻增加是两种相对膜电阻同时变化的结果。
