Department of Dermatology, Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Lasers Surg Med. 2022 Apr;54(4):502-510. doi: 10.1002/lsm.23501. Epub 2021 Dec 2.
Corticosteroids have been the mainstay of treatment for alopecia areata (AA). Recently, the 308-nm excimer laser has been proposed for treating AA.
To compare the efficacy and safety of excimer laser with intralesional corticosteroid (ILCS) in AA.
Patients with at least two alopecic patches were randomly assigned to receive weekly excimer laser treatments or monthly injections of ILCS. Photographs and trichoscopy images were examined at baseline, the last treatment session, and after one month of follow-up. The hair regrowth score was evaluated on a 6-point scale.
Sixteen patients with 99 alopecic patches completed the study. At the last treatment session, the mean score of hair regrowth for the laser was significantly lower than the ILCS (p = 0.003). However, after a month of follow-up, the difference was not statistically significant (p = 0.148). Positive response in hair regrowth (≥50%) was achieved in 47% of laser-treated patches and 66% in ILCS-treated ones. Four (25%) and 8 (50%) patients experienced severe adverse events of laser and ILCS, respectively.
The excimer laser was safe and effective in AA. The effect of laser on hair regrowth might be delayed as compared with ILCS.
皮质类固醇一直是斑秃（AA）治疗的主要方法。最近，308nm 准分子激光被提议用于治疗 AA。
比较准分子激光与皮质内固醇（ILCS）治疗 AA 的疗效和安全性。
至少有两个脱发斑块的患者被随机分配接受每周准分子激光治疗或每月皮质内固醇注射。在基线、最后一次治疗时和随访一个月后检查照片和 trichoscopy 图像。毛发再生评分采用 6 分制评估。
16 名患者 99 个脱发斑块完成了研究。在最后一次治疗时，激光组的毛发再生平均评分明显低于皮质内固醇组（p=0.003）。然而，一个月的随访后，差异无统计学意义（p=0.148）。激光治疗组的毛发再生阳性反应（≥50%）为 47%，皮质内固醇组为 66%。激光和皮质内固醇组分别有 4 名（25%）和 8 名（50%）患者出现严重不良事件。
准分子激光治疗 AA 安全有效。与皮质内固醇相比，激光对毛发再生的作用可能会延迟。
