Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Photodermatol Photoimmunol Photomed. 2020 Nov;36(6):460-469. doi: 10.1111/phpp.12596. Epub 2020 Aug 24.
The excimer laser/light (EL) has been reported to be effective for alopecia areata (AA), but its treatment response has not been systematically reviewed.
To determine the treatment response and safety of EL treatment of AA.
A comprehensive search of the Medline, EMBASE, Cochrane library, and Web of Science (from inception to December 31, 2018) was conducted to identify prospective clinical studies assessing the treatment response of EL for AA. The primary outcome was cosmetically acceptable hair regrowth (hair regrowth ≥75%); random-effects meta-analyses using generic inverse variance weighting were performed to estimate treatment responses. The study was registered with PROSPERO (CRD42019121092).
Of 52 records initially identified, 13 full-text articles were finally assessed in terms of eligibility. A total of 9 prospective clinical studies (129 AA patients) including 5 controlled clinical trials were identified. Cosmetically acceptable hair regrowth was achieved in 50.2% (95% confidence interval 31.5%-68.9%; 8 studies). EL treatment significantly improved hair regrowth compared with untreated controls (relative risk 7.83; 95% confidence interval 2.11-29.11; 5 controlled clinical trials). No serious adverse effect was noted.
EL treatment appeared to produce a favorable therapeutic response in AA patients. The use of EL should be encouraged for AA patients with the advantages of the non-invasiveness and no systemic effect.
准分子激光/光（EL）已被报道对斑秃（AA）有效，但尚未对其治疗效果进行系统评价。
评估 EL 治疗 AA 的疗效和安全性。
通过全面检索 Medline、EMBASE、Cochrane 图书馆和 Web of Science（从建库至 2018 年 12 月 31 日），收集评估 EL 治疗 AA 的疗效的前瞻性临床研究。主要结局指标为美容可接受的毛发再生（毛发再生≥75%）；采用基于广义逆方差的随机效应模型进行 meta 分析，以评估治疗反应。该研究已在 PROSPERO（CRD42019121092）注册。
最初共确定了 52 条记录，最终有 13 篇全文文章符合纳入标准。共纳入 9 项前瞻性临床研究（共 129 例 AA 患者），其中包括 5 项对照临床试验。美容可接受的毛发再生率为 50.2%（95%置信区间为 31.5%-68.9%；8 项研究）。与未治疗对照组相比，EL 治疗显著改善了毛发再生（相对风险 7.83；95%置信区间为 2.11-29.11；5 项对照临床试验）。未观察到严重不良事件。
EL 治疗似乎对 AA 患者产生了良好的治疗效果。鉴于 EL 治疗具有非侵入性和无全身作用的优点，应鼓励 AA 患者使用 EL。
