表皮生长因子对伤口愈合的刺激作用。一种剂量依赖性效应。
Stimulation of wound healing by epidermal growth factor. A dose-dependent effect.
作者信息
Laato M, Niinikoski J, Lebel L, Gerdin B
出版信息
Ann Surg. 1986 Apr;203(4):379-81. doi: 10.1097/00000658-198604000-00007.
Abstract
This work was undertaken to study the effects of various doses of locally applied epidermal growth factor (EGF) on developing granulation tissue in rats. Cylindrical hollow sponge implants were used as an inductive matrix for the growth of granulation tissue. In the test groups, the implants were injected daily with a solution containing 0.2, 1, or 5 micrograms of EGF in 0.1% albumin while the implants of the control group were treated correspondingly with the carrier solution only. Analyses of granulation tissue in the sponge cylinders were carried out 7 days after implantation. A stimulatory, dose-dependent effect of EGF on granulation tissue formation was observed: cellularity increased, as evidenced by the elevated amounts of nucleic acids, and accumulation of collagen and glycosaminoglycans was enhanced.
摘要
本研究旨在探讨不同剂量的局部应用表皮生长因子（EGF）对大鼠肉芽组织发育的影响。采用圆柱形中空海绵植入物作为肉芽组织生长的诱导基质。在试验组中，每天向植入物注射含0.2、1或5微克EGF的0.1%白蛋白溶液，而对照组的植入物仅用载体溶液进行相应处理。植入7天后对海绵圆柱体中的肉芽组织进行分析。观察到EGF对肉芽组织形成具有刺激作用，且呈剂量依赖性：细胞数量增加，表现为核酸含量升高，胶原蛋白和糖胺聚糖的积累也增强。
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