Kim Ji Hyeon, Kang Dong Won, Yun Hongyeol, Kang Minjung, Singh Nem, Kim Jong Seung, Hong Chang Seop
Department of Chemistry, Korea University, Seoul 02841, Korea.
Chem Soc Rev. 2022 Jan 4;51(1):43-56. doi: 10.1039/d1cs00804h.
Porous organic polymers (POPs) are prepared by crosslinked polymerization of multidimensional rigid aromatic building blocks. Generally, POPs can be classified into crystalline covalent organic frameworks (COFs) and other poorly crystalline or amorphous porous polymers. Due to their remarkable intrinsic properties, such as high porosity, stability, tunability, and presence of numerous building blocks, several new POPs are being developed for application across various scientific fields. The essential sensitive functional groups needed for specific applications are not sustained under harsh POP preparation conditions. The recently developed post-synthetic modification (PSM) strategies for POPs have enabled their advanced applications that are otherwise restricted. Owing to the advanced PSM strategies POPs have experienced a blossoming resurgence with diverse functions, particularly in biomedical applications, such as bioimaging tools, drugs, enzymes, gene or protein delivery systems, phototherapy, and cancer therapy. This tutorial review focuses on the recently developed PSM strategies for POPs, especially for biomedical applications, and their future perspectives as promising bioapplicable materials.
多孔有机聚合物（POPs）是通过多维刚性芳香族结构单元的交联聚合制备而成。通常，POPs可分为结晶性共价有机框架（COFs）和其他结晶性较差或无定形的多孔聚合物。由于其具有高孔隙率、稳定性、可调节性以及存在大量结构单元等显著的固有特性，几种新型POPs正在被开发用于各个科学领域。特定应用所需的关键敏感官能团在苛刻的POP制备条件下无法得以维持。最近开发的POPs后合成修饰（PSM）策略使其能够实现原本受限的高级应用。得益于先进的PSM策略，POPs凭借多样的功能经历了蓬勃复兴，尤其在生物医学应用方面，如生物成像工具、药物、酶、基因或蛋白质递送系统、光疗以及癌症治疗。本综述着重介绍了最近开发的POPs的PSM策略，特别是用于生物医学应用的策略，以及它们作为有前景的生物适用材料的未来前景。
