Key Laboratory of Functional Molecular Solids, Ministry of Education, and Anhui Key Laboratory of Chemo/Biosensing, Laboratory of Biosensing and Bioimaging (LOBAB), and School of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241002, China.
Department of Materials Science and Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR 999077, China.
ACS Nano. 2023 Feb 14;17(3):1879-1905. doi: 10.1021/acsnano.2c11346. Epub 2023 Jan 30.
Covalent organic frameworks (COFs) are a type of crystalline organic porous material with specific features and interesting structures, including porosity, large surface area, and biocompatibility. These features enable COFs to be considered as excellent candidates for applications in various fields. Recently, COFs have been widely demonstrated as promising materials for biomedical applications because of their excellent physicochemical properties and ultrathin structures. In this review, we cover the recent progress of COF materials for applications in photodynamic therapy, gene delivery, photothermal therapy, drug delivery, bioimaging, biosensing, and combined therapies. Moreover, the critical challenges and further perspectives with regards to COFs for future biology-facing applications are also discussed.
共价有机框架（COFs）是一种具有特定特征和有趣结构的结晶有机多孔材料，包括多孔性、大表面积和生物相容性。这些特性使 COFs 成为在各个领域应用的优秀候选材料。最近，由于其优异的物理化学性质和超薄结构，COFs 已被广泛证明是生物医学应用的有前途的材料。在这篇综述中，我们介绍了 COF 材料在光动力治疗、基因传递、光热治疗、药物传递、生物成像、生物传感和联合治疗中的应用的最新进展。此外，还讨论了 COFs 在未来面向生物学应用方面所面临的关键挑战和进一步的前景。
