Carvalho Sílvia, Pires João, Moiteiro Cristina, Pinto Moisés L
CERENA, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Campus Alameda, 1049-001 Lisboa, Portugal.
CQE, Centro de Química Estrutural, Institute of Molecular Sciences, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.
Materials (Basel). 2023 Feb 16;16(4):1655. doi: 10.3390/ma16041655.
Hydrogen sulfide (HS) and nitric oxide (NO) are especially known as toxic and polluting gases, yet they are also endogenously produced and play key roles in numerous biological processes. These two opposing aspects of the gases highlight the need for new types of materials to be developed in addition to the most common materials such as activated carbons and zeolites. Herein, a new imine-linked polymer organic framework was obtained using the inexpensive and easy-to-access reagents isophthalaldehyde and 2,4,6-triaminopyrimidine in good yield (64%) through the simple and catalyst-free Schiff-base reaction. The polymeric material has microporosity, an surface area of 51 m/g, and temperature stability up to 300 °C. The obtained 2,4,6-triaminopyrimidine imine-linked polymer organic material has a higher capacity to adsorb NO (1.6 mmol/g) than HS (0.97 mmol/g). Release studies in aqueous solution showed that HS has a faster release (3 h) from the material than NO, for which a steady release was observed for at least 5 h. This result is the first evaluation of the possibility of an imine-linked polymer organic framework being used in the therapeutic release of NO or HS.
硫化氢（HS）和一氧化氮（NO）尤其被认为是有毒和污染性气体，但它们也是内源性产生的，并且在众多生物过程中发挥关键作用。气体的这两个相反方面凸显了除了活性炭和沸石等最常见材料之外，还需要开发新型材料。在此，通过简单且无催化剂的席夫碱反应，使用廉价且易于获取的试剂间苯二甲醛和2,4,6-三氨基嘧啶，以良好的产率（64%）获得了一种新的亚胺连接的聚合物有机骨架。该聚合物材料具有微孔性，比表面积为51 m²/g，热稳定性高达300°C。所获得的2,4,6-三氨基嘧啶亚胺连接的聚合物有机材料对NO的吸附容量（1.6 mmol/g）高于HS（0.97 mmol/g）。在水溶液中的释放研究表明，HS从材料中的释放速度比NO快（3小时），而NO在至少5小时内观察到稳定释放。这一结果首次评估了亚胺连接的聚合物有机骨架用于NO或HS治疗性释放的可能性。
