de Luis D, Izaola O, Primo D, Pacheco D
Endocrinology and Nutrition Research Center, School of Medicine, Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Eur Rev Med Pharmacol Sci. 2021 Nov;25(22):7037-7043. doi: 10.26355/eurrev_202111_27254.
Genetic mechanisms have been involved in the pathogenesis of obesity and weight loss due to bariatric surgery. The aim of our work was to evaluate the effects of rs2419621 genetic variant of ACSL5 gene on weight and metabolic changes after a robotic sleeve gastrectomy.
48 patients were enrolled. Comorbidities, biochemical and anthropometric parameters evaluation were registered before and after 3, 6 and 12 months follow up. Genotype of rs2419621 ACSL5 gene was evaluated.
We classified the subjects with a dominant model, in two groups: those carriers T allele (TT+CT, 37.5%) and non-carriers T allele (CC, 62.5%). We reported a statistically significant reduction of body weight, waist circumference, percentage of excess of weight loss (EWL%), blood pressure, glucose, insulin, LDL-cholesterol and triglycerides after surgery. After 12 months, delta of (EWL%; 70.1% vs. 64,2%; p=0.04), weight (40.7+4.1 kg vs. 32.5+4.8 kg; p=0.03), waist circumference (29.1+3.1 cm vs. 22.2+2.8 kg; p=0.02) and triglycerides (51.2+9.1 mg/dl vs. 32.1+8.1; p=0.02) were higher in T allele carriers than non-T allele carriers. All comorbidities improved, but the percentage of patients with hypertriglyceridemia diminished early in the 3-month follow-up in the T-allele carriers, and at 12 months, no patient with the T allele had hypertriglyceridemia.
Our data showed that the genetic variant (rs2419621) of ACSL5 gene are associated with better improvement of adiposity and triglyceride levels in subjects with T allele, after a robotic sleeve gastrectomy.
遗传机制与肥胖症的发病机制以及减肥手术导致的体重减轻有关。我们研究的目的是评估ACSL5基因的rs2419621基因变异对机器人袖状胃切除术后体重和代谢变化的影响。
招募了48名患者。在随访3、6和12个月之前及之后记录合并症、生化和人体测量参数评估结果。评估rs2419621 ACSL5基因的基因型。
我们采用显性模型将受试者分为两组：T等位基因携带者（TT + CT，37.5%）和非T等位基因携带者（CC，62.5%）。我们报告称，术后体重、腰围、超重减轻百分比（EWL%）、血压、血糖、胰岛素、低密度脂蛋白胆固醇和甘油三酯均有统计学意义的显著降低。12个月后，T等位基因携带者的（EWL%；70.1%对64.2%；p = 0.04）、体重（40.7 + 4.1千克对32.5 + 4.8千克；p = 0.03）、腰围（29.1 + 3.1厘米对22.2 + 2.8千克；p = 0.02）和甘油三酯（51.2 + 9.1毫克/分升对32.1 + 8.1；p = 0.02）的变化值高于非T等位基因携带者。所有合并症均有所改善，但T等位基因携带者在3个月随访早期高甘油三酯血症患者的百分比有所下降，且在12个月时，没有T等位基因的患者患有高甘油三酯血症。
我们的数据表明，ACSL5基因的基因变异（rs2419621）与机器人袖状胃切除术后T等位基因受试者的肥胖和甘油三酯水平的更好改善相关。
