单个 FTO 基因变异 rs9939609 与严重肥胖个体机器人袖状胃切除术后体重变化和胰岛素抵抗改善相关。

A single FTO gene variant rs9939609 is associated with weight change and insulin resistance improvement in response to a robotic sleeve gastrectomy in individuals with severe obesity.

机构信息

Endocrinology and Nutrition Research Center, School of Medicine, Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.

出版信息

Surg Obes Relat Dis. 2023 May;19(5):459-465. doi: 10.1016/j.soard.2022.10.035. Epub 2022 Nov 7.

DOI:10.1016/j.soard.2022.10.035

PMID:36509673

Abstract

BACKGROUND

Genetic mechanisms have been involved in the weight response secondary to bariatric surgery.

OBJECTIVE

The aim of our study was to evaluate the effects of the rs9939609 genetic variant on weight loss and metabolic parameters after sleeve gastrectomy.

SETTING

Tertiary hospital.

METHODS

A total of 95 participants were enrolled. Co-morbidities, biochemical evaluation, and anthropometric parameters were registered before and after 3-, 6-, and 12-month follow-up. Genotype of the rs9939609 fat mass and obesity-associated (FTO) gene was evaluated.

RESULTS

We grouped the participants into 2 groups: carriers of A allele (TA+AA, 69.5%) and noncarriers of A allele (TT, 30.5%). We detected a statistically significant reduction of blood pressure, biochemical, and anthropometric parameters at 3 times during follow-up. After 6 months, changes of some parameters were greater in non-A allele carriers: weight (-39.6 + 4.0 kg versus -24.6 + 2.8 kg; P = .02), waist circumference (-21.1 + 2.1 cm versus -16.2 + 1.8 cm; P = .04), insulin (-12.3 + .9 mUI/L versus -8.9.1 + .2 mUI/L; P = .02), and homeostasis model assessment of insulin resistance (-3.1 + .1 units versus -2.3 + .1 units; P = .02 ). After 12 months, changes of the aforementioned parameters remained greater in non-A allele carriers. The percentage of participants with diabetes diminished earlier in the non-A allele carriers than A allele carriers at 6-month follow-up. The percentage of participants with diabetes at the end of the study was lower in non-A allele carriers (3.4% versus 12.1%; P = .02).

CONCLUSIONS

Our data suggest that non-A allele carriers of the genetic variant (rs9939609) of the FTO gene showed a better improvement of anthropometric and insulin levels in non-A allele carriers after a robotic sleeve gastrectomy. Both improvements are associated with a lower percentage of participants with diabetes at 12 months.

摘要

背景

遗传机制与减重手术后的体重反应有关。

目的

本研究旨在评估 rs9939609 基因变异对袖状胃切除术减肥和代谢参数的影响。

设置

三级医院。

方法

共纳入 95 例患者。在术后 3、6 和 12 个月的随访中，记录合并症、生化评估和人体测量参数。评估 rs9939609 脂肪量和肥胖相关（FTO）基因的基因型。

结果

我们将患者分为 2 组：A 等位基因携带者（TA+AA，69.5%）和非 A 等位基因携带者（TT，30.5%）。我们在随访期间的 3 次随访中检测到血压、生化和人体测量参数均有统计学显著降低。6 个月后，非 A 等位基因携带者的某些参数变化更大：体重（-39.6+4.0kg 与-24.6+2.8kg；P=0.02）、腰围（-21.1+2.1cm 与-16.2+1.8cm；P=0.04）、胰岛素（-12.3+0.9mIU/L 与-8.9+0.2mIU/L；P=0.02）和稳态模型评估的胰岛素抵抗（-3.1+0.1 单位与-2.3+0.1 单位；P=0.02）。12 个月后，非 A 等位基因携带者的上述参数变化仍较大。6 个月时，非 A 等位基因携带者的糖尿病患者比例比 A 等位基因携带者更早下降。研究结束时，非 A 等位基因携带者的糖尿病患者比例较低（3.4%与 12.1%；P=0.02）。