Hepatobiliary Pancreas, Breast and Thyroid Surgery Ward, The People's Hospital of Kaizhou District, Chongqing, China.
Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Drug Dev Res. 2022 May;83(3):708-720. doi: 10.1002/ddr.21902. Epub 2021 Dec 3.
Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid cancer. Studies have shown that platycodin D has several pharmacological effects like anti-inflammatory, immunomodulatory, and anti-tumor effects, while the effect and mechanism of platycodin D on PTC are still unclear. This study was designed to investigate the effects of platycodin D on PTC by a series of in vitro and in vivo experiments. The results revealed that platycodin D inhibits PTC cell viability and clonal levels and affects PTC cell cycle. Platycodin D promotes apoptosis in PTC cells. Furthermore, it inhibits the activation of NF-κB signaling pathway and affects cell growth. Platycodin D inhibits PD-L1 expression and enhances the effect of pembrolizumab on PTC cells. In conclusion, platycodin D can effectively block the progression of PTC through the NF-κB signaling pathway, accompanied by cell cycle arrest and enhanced cell apoptosis. In vitro and in vivo, platycodin D was shown to enhance pembrolizumab's sensitivity to PTC. Platycodin D is a promising monomer for therapy of PTC, providing references for future research on PTC treatment.
甲状腺乳头状癌（PTC）是最常见的甲状腺癌病理类型。研究表明，桔梗皂苷 D 具有抗炎、免疫调节和抗肿瘤等多种药理作用，而桔梗皂苷 D 对 PTC 的作用及机制尚不清楚。本研究通过一系列的体外和体内实验，旨在探讨桔梗皂苷 D 对 PTC 的影响。结果表明，桔梗皂苷 D 抑制 PTC 细胞活力和集落水平，并影响 PTC 细胞周期。桔梗皂苷 D 促进 PTC 细胞凋亡。此外，它还抑制 NF-κB 信号通路的激活，影响细胞生长。桔梗皂苷 D 抑制 PD-L1 的表达，增强了 pembrolizumab 对 PTC 细胞的作用。综上所述，桔梗皂苷 D 能有效通过 NF-κB 信号通路阻断 PTC 的进展，同时伴有细胞周期阻滞和增强细胞凋亡。在体外和体内，桔梗皂苷 D 均显示出增强 pembrolizumab 对 PTC 的敏感性。桔梗皂苷 D 是治疗 PTC 的一种很有前途的单体，为 PTC 治疗的未来研究提供了参考。
