Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Centro Medicina dell'Invecchiamento, Fondazione Policlinico "A- Gemelli" IRCCS and Catholic University of Rome, Rome, Italy.
Alzheimers Dement. 2022 Oct;18(10):1779-1787. doi: 10.1002/alz.12495. Epub 2021 Dec 3.
Resting heart rate (RHR) predicts future risk for cardiovascular disease (CVD). However, longitudinal studies investigating the relationship of RHR with cognitive decline are scarce.
This population-based cohort study included 2147 participants (age≥60) in SNAC-K who were free of dementia and regularly followed from 2001-2004 to 2013-2016. RHR was assessed with electrocardiogram. Dementia was diagnosed following the Diagnostic and Statistical Manual of Mental Disorders 4th Revision criteria. Global cognitive function was assessed using Mini-Mental State Examination (MMSE). Data were analyzed using Cox and linear mixed-effects models.
RHR≥80 (vs. 60-69) bpm was associated with a multi-adjusted hazard ratio of 1.55 (95% confidence interval 1.06-2.27) for dementia. The association remained significant after excluding participants with prevalent and incident CVDs. Similarly, RHR≥80 bpm was associated with a multi-adjusted β-coefficient of -0.13 (-0.21 to -0.04) for MMSE score.
Higher RHR is associated with increased risk for dementia and faster cognitive decline independent of CVDs in a general population of elderly people.
静息心率（RHR）可预测未来心血管疾病（CVD）的风险。然而，关于 RHR 与认知能力下降之间关系的纵向研究还很少。
这项基于人群的队列研究纳入了 SNAC-K 中 2147 名（年龄≥60 岁）无痴呆且从 2001-2004 年至 2013-2016 年定期随访的参与者。通过心电图评估 RHR。痴呆的诊断依据是《精神障碍诊断与统计手册》第 4 版标准。使用简易精神状态检查（MMSE）评估整体认知功能。使用 Cox 和线性混合效应模型进行数据分析。
RHR≥80（与 60-69 相比）bpm 与痴呆的多调整风险比为 1.55（95%置信区间 1.06-2.27）。在排除了患有现患和新发 CVD 的参与者后，该关联仍然显著。同样，RHR≥80 bpm 与 MMSE 评分的多调整β系数为-0.13（-0.21 至-0.04）。
在一般老年人群中，RHR 较高与痴呆风险增加和认知能力下降速度加快独立于 CVD 相关。
