静息心率与老年人认知能力下降和痴呆的关系：一项基于人群的队列研究。
Association of resting heart rate with cognitive decline and dementia in older adults: A population-based cohort study.
机构信息
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Centro Medicina dell'Invecchiamento, Fondazione Policlinico "A- Gemelli" IRCCS and Catholic University of Rome, Rome, Italy.
出版信息
Alzheimers Dement. 2022 Oct;18(10):1779-1787. doi: 10.1002/alz.12495. Epub 2021 Dec 3.
INTRODUCTION
Resting heart rate (RHR) predicts future risk for cardiovascular disease (CVD). However, longitudinal studies investigating the relationship of RHR with cognitive decline are scarce.
METHODS
This population-based cohort study included 2147 participants (age≥60) in SNAC-K who were free of dementia and regularly followed from 2001-2004 to 2013-2016. RHR was assessed with electrocardiogram. Dementia was diagnosed following the Diagnostic and Statistical Manual of Mental Disorders 4th Revision criteria. Global cognitive function was assessed using Mini-Mental State Examination (MMSE). Data were analyzed using Cox and linear mixed-effects models.
RESULTS
RHR≥80 (vs. 60-69) bpm was associated with a multi-adjusted hazard ratio of 1.55 (95% confidence interval 1.06-2.27) for dementia. The association remained significant after excluding participants with prevalent and incident CVDs. Similarly, RHR≥80 bpm was associated with a multi-adjusted β-coefficient of -0.13 (-0.21 to -0.04) for MMSE score.
DISCUSSION
Higher RHR is associated with increased risk for dementia and faster cognitive decline independent of CVDs in a general population of elderly people.
简介
静息心率（RHR）可预测未来心血管疾病（CVD）的风险。然而，关于 RHR 与认知能力下降之间关系的纵向研究还很少。
方法
这项基于人群的队列研究纳入了 SNAC-K 中 2147 名（年龄≥60 岁）无痴呆且从 2001-2004 年至 2013-2016 年定期随访的参与者。通过心电图评估 RHR。痴呆的诊断依据是《精神障碍诊断与统计手册》第 4 版标准。使用简易精神状态检查（MMSE）评估整体认知功能。使用 Cox 和线性混合效应模型进行数据分析。
结果
RHR≥80（与 60-69 相比）bpm 与痴呆的多调整风险比为 1.55（95%置信区间 1.06-2.27）。在排除了患有现患和新发 CVD 的参与者后，该关联仍然显著。同样，RHR≥80 bpm 与 MMSE 评分的多调整β系数为-0.13（-0.21 至-0.04）。
讨论
在一般老年人群中，RHR 较高与痴呆风险增加和认知能力下降速度加快独立于 CVD 相关。
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