氧化平衡评分与死亡率的关系：SUN 队列的前瞻性分析。
Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort.
机构信息
Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, C/ Irunlarrea, 31008, Pamplona, Spain.
IdisNA, Navarra Institute for Health Research, 31008, Pamplona, Spain.
出版信息
Eur J Nutr. 2023 Jun;62(4):1667-1680. doi: 10.1007/s00394-023-03099-8. Epub 2023 Feb 12.
PURPOSE
We aimed to prospectively investigate the association of an overall oxidative balance score (OBS) with all-cause death and cause-specific mortality among participants in the Seguimiento Universidad de Navarra (SUN) Study, a Mediterranean cohort of Spanish graduates.
METHODS
Using baseline information on 12 a priori selected dietary and non-dietary lifestyle pro- and antioxidants exposures-vitamins C and E, β-carotenes, selenium, zinc, heme iron, polyphenols, total antioxidant capacity, body mass index, alcohol, smoking, and physical activity-we constructed an equally weighted OBS categorized into quartiles, with higher scores representing greater antioxidant balance. Cox proportional hazards models were fitted to evaluate the association between the OBS and mortality.
RESULTS
A total of 18,561 participants (mean [SD] age, 38.5 [12.4] years; 40.8% males) were included in the analysis. During a median follow-up of 12.2 years (interquartile range 8.3-14.9), 421 deaths were identified, including 80 deaths from cardiovascular disease (CVD), 215 from cancer, and 126 from other causes. After adjustment for potential confounders, the hazard ratios and 95% confidence interval (CIs) between the highest quartile (predominance of antioxidants) vs. the lowest quartile (reference category) were 0.35 (95% CI 0.22-0.54, P-trend < 0.001) for all-cause mortality, 0.18 (95% CI 0.06-0.51, P-trend = 0.001) for CVD mortality, 0.35 (95% CI 0.19-0.65, P-trend = 0.002) for cancer mortality, and 0.45 (95% CI 0.20-1.02, P-trend = 0.054) for other-cause mortality.
CONCLUSION
Our findings suggest a strong inverse association between the OBS and all-cause, CVD, and cancer mortality. Individuals exposed to both antioxidant dietary and lifestyle factors may potentially experience the lowest mortality risk.
STUDY REGISTRY NUMBER
Dynamic Mediterranean Prospective Cohort: the SUN Project; NCT02669602. https://clinicaltrials.gov/ct2/show/NCT02669602 . https://proyectosun.es.
目的
我们旨在前瞻性研究总体氧化平衡评分（OBS）与西班牙纳瓦拉大学随访研究（SUN）参与者全因死亡和特定原因死亡率之间的关系，该研究是一个地中海西班牙毕业生队列。
方法
使用 12 项预先选择的饮食和非饮食生活方式促氧化剂和抗氧化剂暴露的基线信息-维生素 C 和 E、β-胡萝卜素、硒、锌、血红素铁、多酚、总抗氧化能力、体重指数、酒精、吸烟和身体活动-我们构建了一个同等权重的 OBS 分类为四分位数，得分越高表示抗氧化平衡越好。Cox 比例风险模型用于评估 OBS 与死亡率之间的关系。
结果
共纳入 18561 名参与者（平均[SD]年龄，38.5[12.4]岁；40.8%为男性）进行分析。在中位数为 12.2 年（四分位间距 8.3-14.9）的随访期间，共确定了 421 例死亡，其中 80 例死于心血管疾病（CVD），215 例死于癌症，126 例死于其他原因。在调整潜在混杂因素后，最高四分位数（抗氧化剂为主）与最低四分位数（参考类别）之间的全因死亡率、CVD 死亡率、癌症死亡率和其他原因死亡率的风险比（HR）和 95%置信区间（CI）分别为 0.35（95%CI 0.22-0.54，P-趋势<0.001）、0.18（95%CI 0.06-0.51，P-趋势=0.001）、0.35（95%CI 0.19-0.65，P-趋势=0.002）和 0.45（95%CI 0.20-1.02，P-趋势=0.054）。
结论
我们的研究结果表明，OBS 与全因、CVD 和癌症死亡率之间存在很强的负相关。接触抗氧化饮食和生活方式因素的个体可能具有最低的死亡风险。
研究注册号
动态地中海前瞻性队列：SUN 项目；NCT02669602。https://clinicaltrials.gov/ct2/show/NCT02669602。https://proyectosun.es。
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