Baer M R, Krantz S B, Cousar J B, Glick A D, Collins R D
Cancer. 1986 Jun 1;57(11):2175-84. doi: 10.1002/1097-0142(19860601)57:11<2175::aid-cncr2820571116>3.0.co;2-r.
Two patients with indolent B-cell lymphomas (small B-cell and small cleaved cell) developed a coexistent malignant histiocytosis 3 and 6 years after diagnosis of their lymphomas. In both patients, malignant histiocytosis presented as new onset of fever, weight loss, and rapidly progressive bulky disease super-imposed on a previously stable clinical course without constitutional symptoms. Both patients failed to respond to combination chemotherapy. The terminal aggressive phase of indolent B-cell lymphomas usually represents transformation of the original neoplasm to a large non-cleaved or immunoblastic B-cell histology. Malignant histiocytosis has not previously been reported as a second neoplasm in patients with B-cell lymphomas.
两名惰性B细胞淋巴瘤（小B细胞和小裂细胞）患者在淋巴瘤诊断后3年和6年出现了并存的恶性组织细胞增多症。在这两名患者中，恶性组织细胞增多症表现为发热、体重减轻的新症状，以及在先前稳定的临床病程中突然出现的快速进展的大块病变，且无全身症状。两名患者对联合化疗均无反应。惰性B细胞淋巴瘤的终末期侵袭性阶段通常代表原始肿瘤转变为大无裂或免疫母细胞性B细胞组织学类型。恶性组织细胞增多症此前未被报道为B细胞淋巴瘤患者的第二种肿瘤。
