Department of Mechanical Engineering, Government College of Technology, Coimbatore, India.
J Biomater Sci Polym Ed. 2022 Apr;33(6):727-746. doi: 10.1080/09205063.2021.2014028. Epub 2021 Dec 16.
Polyether Ether Ketone (PEEK) exhibits superior mechanical and biological safety characteristics, and its biological inertness significantly restricts its applicability in biomedical applications. Recent researches included active ceramic particles to enhance biological activity and broaden the application range of bioactive composites in medical implants. During the current investigation, acrylic acid-functionalized ceramic TiO and SiO nanoparticles (NP) were used to reinforce the PEEK matrix. The PEEK/TiO/SiO (PTS) nanocomposite was fabricated using plastic injection moulding process. Different functional groups and crystal plane orientations of the composite were found through FTIR and XRD. The morphological and elemental analysis were carried out using FESEM and the EDAX mapping technique. The thermal stability of the composite was investigated through TGA and DSC analysis. The mean diameter of the inhibition zone of PTS polymer composite is 18.125 mm and 16.375 mm against and , respectively, which is higher than that of the mean diameter of the inhibition zone of PEEK. direct and indirect cytotoxicity studies were carried using the MG-63 cell line and found the cell viability as 94.30% and cytotoxicity as 5.70% on PTS nanocomposite. Cell adhesion study was carried out using MG-63 cell line on the composite surface. That demonstrated the good cell adherence and cell proliferation those were observed through SEM morphologies. Thus, the newly developed composite serves as a potential candidate in biomedical applications.
聚醚醚酮（PEEK）具有优异的机械和生物安全性，但其生物惰性显著限制了其在生物医学应用中的适用性。最近的研究包括添加活性陶瓷颗粒来提高生物活性，并拓宽生物活性复合材料在医学植入物中的应用范围。在当前的研究中，使用了丙烯酸功能化陶瓷 TiO 和 SiO 纳米粒子（NP）来增强 PEEK 基体。通过塑料注塑成型工艺制备了 PEEK/TiO/SiO（PTS）纳米复合材料。通过 FTIR 和 XRD 发现了复合材料的不同官能团和晶体平面取向。通过 FESEM 和 EDAX 映射技术进行了形态和元素分析。通过 TGA 和 DSC 分析研究了复合材料的热稳定性。PTS 聚合物复合材料对 和 的抑菌圈平均直径分别为 18.125mm 和 16.375mm，高于 PEEK 的抑菌圈平均直径。通过 MG-63 细胞系进行了 PTS 纳米复合材料的直接和间接细胞毒性研究，发现细胞活力为 94.30%，细胞毒性为 5.70%。在复合表面上通过 MG-63 细胞系进行了细胞黏附研究。通过 SEM 形态观察到了良好的细胞黏附和增殖。因此，新开发的复合材料可作为生物医学应用中的潜在候选材料。
