Department of Paediatrics C, Schneider Children's Medical Center, Petah Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Acta Paediatr. 2022 Mar;111(3):614-619. doi: 10.1111/apa.16207. Epub 2021 Dec 11.
Adenovirus infections are exceedingly common in childhood. However, little is known of the clinical characteristics of children admitted with severe infection to the paediatric intensive care unit (PICU).
Clinical data on children hospitalised with adenovirus infection between January 2005 and March 2020 were collected. We compared data between children hospitalised in the PICU and those who were not in a 1:2 ratio.
During the study period, 69 children with adenovirus infection were admitted to the PICU, representing 5% of all hospitalised children with adenovirus. Thirty-four (49%) were previously healthy children. Mortality occurred in 5 patients, and all had an underlying illness. Cidofovir was used in 21 children, including 11 who were previously healthy. No side effects were attributed to the treatment. During 2005-2014, viral co-infection rates were 42% in the PICU group and 11% in the control group (p = 0.002). However, during 2015-2020, when the viral panel became widespread in our institution, the rates of co-infection were similar in the two groups (32% and 34%, p = 1.0).
Our findings suggest that adenovirus may present as a serious, life-threatening disease even in previously healthy children.
腺病毒感染在儿童中极为常见。然而，对于因严重感染而入住儿科重症监护病房（PICU）的儿童的临床特征，人们知之甚少。
收集了 2005 年 1 月至 2020 年 3 月期间因腺病毒感染住院的儿童的临床数据。我们比较了入住 PICU 与未入住 PICU 的儿童数据，比例为 1:2。
在研究期间，69 例腺病毒感染患儿入住 PICU，占所有腺病毒感染住院患儿的 5%。34 例（49%）患儿既往健康。5 例患儿死亡，均有基础疾病。21 例患儿使用了更昔洛韦，其中 11 例既往健康。治疗无不良反应。2005-2014 年，PICU 组病毒合并感染率为 42%，对照组为 11%（p=0.002）。然而，在 2015-2020 年，当我院广泛开展病毒检测时，两组的合并感染率相似（32%和 34%，p=1.0）。
我们的研究结果表明，腺病毒即使在既往健康的儿童中也可能表现为严重的、危及生命的疾病。
