Xu Ying, Xu Li, Zheng Yu
Department of Traditional Chinese medicine, Wuxi Second People's Hospital, Zhongshan Road, Wuxi, China.
Department of Acupuncture and Moxibustion, Wuxi Second People's Hospital, Zhongshan Road, Wuxi, China.
Pak J Pharm Sci. 2021 Sep;34(5(Special)):2027-2033.
To explore the application of Chaihu-Guizhi-Longgu-Muli decoction (CGLM) combined with Liuwei Dihuang Pills in the treatment of menopausal insomnia and its effect on sleep quality. The data of 120 menopausal insomnia patients admitted to our hospital from February 2019 to February 2020 were retrospectively analyzed and they were equally divided into the experimental group (n=60) and the control group (n=60) according to the order of admission. All patients were treated with Liuwei Dihuang Pills, and the experimental group was additionally given CGLM. The Pittsburgh Sleep Quality Index (PSQI), estrogen level, negative emotion score, quality of life score, serum β-endorphin (β-EP) level, serotonin level (5-HT) and treatment effective rate were compared between the two groups of patients. After treatment, the experimental group obtained markedly lower PSQI scores and negative emotion scores than the control group (P<0.001). The estrogen levels, β-EP levels and 5-HT levels of the experimental group after treatment were significantly better than those of the control group (P<0.001). Higher quality of life scores and treatment effective rates were observed in the experimental group after treatment than the control group (P<0.001). CGLM combined with Liuwei Dihuang Pills can regulate the serum hormone levels of patients with menopausal insomnia, reduce negative emotions and improve sleep quality and quality of life, which merits clinical promotion.
探讨柴胡加龙骨牡蛎汤联合六味地黄丸治疗绝经后失眠的应用及其对睡眠质量的影响。回顾性分析2019年2月至2020年2月我院收治的120例绝经后失眠患者的资料，按照入院顺序将其分为实验组（n = 60）和对照组（n = 60）。所有患者均给予六味地黄丸治疗，实验组加用柴胡加龙骨牡蛎汤。比较两组患者的匹兹堡睡眠质量指数（PSQI）、雌激素水平、负性情绪评分、生活质量评分、血清β-内啡肽（β-EP）水平、5-羟色胺水平（5-HT）及治疗有效率。治疗后，实验组的PSQI评分和负性情绪评分明显低于对照组（P < 0.001）。实验组治疗后的雌激素水平、β-EP水平和5-HT水平明显优于对照组（P < 0.001）。治疗后实验组的生活质量评分和治疗有效率高于对照组（P < 0.001）。柴胡加龙骨牡蛎汤联合六味地黄丸可调节绝经后失眠患者的血清激素水平，减轻负性情绪，改善睡眠质量和生活质量，值得临床推广。
