Wang Zhipeng, Ke Deng, Huang Xiaoqin, Ding Yang, Wang Changsong
J Tradit Chin Med. 2017 Feb;37(1):23-9. doi: 10.1016/s0254-6272(17)30022-5.
To evaluate the effect of Guizhi Gancao Longgu Muli Tang (GGLMT), a decoction prepared with herbal medicine of Traditional Chinese Medicine, on sleep disturbances in women with menopause.
Totally 162 participants were recruited for the treatment of sleep difficulty from February, 2012 to December, 2014. Decoction of 200 mL was taken by every participant twice daily in half an hour after lunch and dinner during two weeks. Sleep quality was assessed by Pittsburg sleep quality index (PSQI) and menopausal symptoms and quality of life were evaluated by the menopause rating scale (MRS) and the Chinese version of World Health Organization quality of life-BREF at the final fellow-up in the fourth weekend after beginning.
The average scores of PSQI had reduced from (13.82 ± 4.97) to (8.14 ± 3.19), 95% CI (－ 4.87, － 3.05) after 2-week GGLMT treatment in the fourth week. GGLMT improved symptoms in patients with more severe conditions (MRS ≥ 16). Three adverse drug reaction, mouth ulcer, constipation, and folliculitis, might be related with GGLMT and disappeared after withdrawals of the treatment.
For menopausal women suffering from chronic sleep disturbances, our findings suggest that two weeks treatment of GGLMT was safe and effective.
评估中药复方桂枝甘草龙骨牡蛎汤（GGLMT）对更年期女性睡眠障碍的影响。
2012年2月至2014年12月，共招募162名睡眠困难患者。每位参与者在两周内，于午餐和晚餐后半小时各服用200 mL汤剂，每日两次。在开始治疗后的第四个周末进行末次随访时，采用匹兹堡睡眠质量指数（PSQI）评估睡眠质量，采用更年期评定量表（MRS）和中文版世界卫生组织生活质量简表（WHOQOL - BREF）评估更年期症状和生活质量。
在第四周，经过2周的GGLMT治疗后，PSQI平均得分从（13.82 ± 4.97）降至（8.14 ± 3.19），95%可信区间为（－ 4.87，－ 3.05）。GGLMT改善了病情较重（MRS≥16）患者的症状。有3例药物不良反应，口腔溃疡、便秘和毛囊炎，可能与GGLMT有关，停药后消失。
对于患有慢性睡眠障碍的更年期女性，我们的研究结果表明，两周的GGLMT治疗安全有效。
