CERTBIO, Universidade Federal de Campina Grande (UFCG), Campina Grande, Paraíba, Brazil.
Programa de Pós-Graduação em Medicina Veterinária (PPGMV), Universidade Federal de Campina Grande (UFCG), Campina Grande, Paraíba, Brazil.
Biomed Mater Eng. 2022;33(3):221-233. doi: 10.3233/BME-211308.
Bone cements aid in bone regeneration; however, if the handling time is not well established for the material to harden, complications may arise.
This work investigates the effect of using polyethylene glycol (PEG) and characterize it in brushite bone cement in order to obtain desirable handling times as well as its regeneration in vivo to analyse if addition of this polymer may significantly modify its properties.
PEG 4000 was synthesised with wollastonite by phosphorization reaction in order to form brushite which was further cured by oven drying. They were further characterised and tested in vivo as tibial bone defect model using rabbits.
Addition of PEG exhibited handling times of 60 min with a low increase in temperature when curing. Brushite phase of ∼71% was obtained after cement hardening with good compressive strength (25 MPa) and decent values of porosity (33%). In vivo presented that, at 40 days postoperatively, accelerated bone neoformation with partial consolidation at 30 days and total after 60 days when using bone cement.
Addition of PEG does not disrupt the beneficial properties of the bone cement and can be a potential alternative to control the time-temperature profile of hardening these materials.
骨水泥有助于骨再生；然而，如果材料硬化的操作时间没有得到很好的确立，可能会出现并发症。
本研究旨在探讨聚乙二醇（PEG）的作用，并对其在 Brushite 骨水泥中的特性进行研究，以获得理想的操作时间，并对其在体内的再生进行分析，以确定添加这种聚合物是否会显著改变其性质。
采用 wollastonite 与磷酸化反应合成 PEG4000，形成 Brushite，然后通过烤箱干燥进行固化。对其进行进一步的特性研究，并在兔子的胫骨骨缺损模型中进行体内测试。
添加 PEG 后，操作时间延长至 60 分钟，固化过程中温度略有升高。水泥硬化后，获得了约 71%的 Brushite 相，具有良好的抗压强度（25MPa）和适中的孔隙率（33%）。体内结果表明，术后 40 天，使用骨水泥可加速骨新形成，术后 30 天部分骨整合，术后 60 天完全骨整合。
PEG 的添加不会破坏骨水泥的有益特性，可能是控制这些材料硬化时的时-温曲线的一种潜在选择。
