Yu Haojun, Lv Jing, Hu Pengcheng, Chen Shuguang, Shi Hongcheng
Department of Nuclear Medicine, Zhongshan Hospital, Fudan University.
Nuclear Medicine Institute of Fudan University.
Nucl Med Commun. 2022 Feb 1;43(2):166-171. doi: 10.1097/MNM.0000000000001506.
This study explored the utility of oral vitamin C in reducing radiation accumulation in the salivary glands during total-body dynamic PET/computed tomography (CT) imaging with 68Ga labeled Prostate-specific membrane antigen (68Ga-PSMA-11).
We enrolled 31 patients who underwent total-body dynamic PET/CT imaging with 68Ga-PSMA-11, of which 11 were given oral vitamin C 30 min after starting the dynamic PET acquisition, whereas the others did not. The volume of interest was automatically segmented on the parotid and submandibular salivary glands once the PET acquisition was completed. The standard uptake value (SUV)mean and its slope during 30-60 min of the acquisition were compared between the trial and control groups.
The SUVmean of the left and right parotid and submandibular glands in the trial group were 15.37 ± 3.07, 15.03 ± 2.64, 14.92 ± 4.38 and 15.38 ± 4.18, respectively. The respective values of the control group were 19.37 ± 3.82, 20.08 ± 3.55, 22.61 ± 5.62 and 22.73 ± 5.90. The SUVmean slope during 30-60 min of acquisition for the left and right parotid and submandibular glands in the trial group were 0.63 ± 0.13, 0.64 ± 0.14, 0.56 ± 0.25 and 0.62 ± 0.26, respectively. The respective values of the control group were 0.84 ± 0.21, 0.84 ± 0.17, 1.01 ± 0.34 and 1.02 ± 0.37.
Oral vitamin C could reduce the accumulation of radiation in the salivary glands during 68Ga-PSMA-11 total-body dynamic PET/CT imaging.
本研究探讨了口服维生素C在68Ga标记前列腺特异性膜抗原（68Ga-PSMA-11）的全身动态正电子发射断层扫描/计算机断层扫描（PET/CT）成像过程中减少唾液腺辐射蓄积的作用。
我们纳入了31例行68Ga-PSMA-11全身动态PET/CT成像的患者，其中11例在动态PET采集开始30分钟后给予口服维生素C，其余患者未给予。PET采集完成后，自动在腮腺和颌下唾液腺上分割感兴趣区。比较试验组和对照组在采集30-60分钟期间的平均标准摄取值（SUV）及其斜率。
试验组左右腮腺和颌下腺的SUVmean分别为15.37±3.07、15.03±2.64、14.92±4.38和15.38±4.18。对照组的相应值分别为19.37±3.82、20.08±3.55、22.61±5.62和22.73±5.90。试验组左右腮腺和颌下腺在采集30-60分钟期间的SUVmean斜率分别为0.63±0.13、0.64±0.14、0.56±0.25和0.62±0.26。对照组的相应值分别为0.84±0.21、0.84±0.17、1.01±0.34和1.02±0.37。
口服维生素C可减少68Ga-PSMA-11全身动态PET/CT成像过程中唾液腺的辐射蓄积。
