Kaya Mehmet Nur, Kılıç Özlem, Doğan Abdullah, Yılmaz Sedat, Tecer Duygu
Rheumatology, Gülhane Training and Research Hospital, Ankara, TUR.
Cureus. 2023 Sep 18;15(9):e45459. doi: 10.7759/cureus.45459. eCollection 2023 Sep.
Our aim in this study was to evaluate the level of central sensitization (CS) in patients having familial Mediterranean fever (FMF), axial spondyloarthritis (axSpA), and both diseases (axSpA/FMF).
This study included 30 FMF, 30 axSpA, 30 axSpA/FMF patients, and 30 healthy controls (HCs). The presence of CS was investigated by the Central Sensitization Inventory (CSI) questionnaire. In order to evaluate the effect of CS on patient groups, clinical features, disease activity, quality of life, sleep quality, depression, and anxiety frequency were examined. The patients were divided into groups according to the presence and severity of CS and their results were compared.
The mean age of all participants was 28.4±5.7 years and 67 (55.8%) of them were male. The erythrocyte sedimentation rate (ESR) value was significantly higher in axSpA and axSpA/FMF groups than in FMF and HCs groups (p<0.001). ESR value was significantly higher in the FMF group than in the HCs group (p<0.001). C-reactive protein (CRP) value was significantly higher in the axSpA/FMF group than in the axSpA and HCs groups (p=0.001). CSI-Part A value was significantly higher in the axSpA, FMF, and axSpA/FMF group than in the HCs group (p<0.001). CSI-Part A value did not differ significantly between axSpA/FMF, axSpA, and FMF groups (p>0.05). The presence of chronic fatigue syndrome was found to be significantly higher in the FMF group than in the axSpA and HCs groups (p<0.05). Fibromyalgia syndrome was significantly higher in the axSpA/FMF group than in the axSpA, FMF, and HCs groups (p<0.05).
In this study, the CS score was found to be significantly higher in axSpA and FMF patients compared to the HCs group. There was no difference between the disease groups in terms of CS score.
本研究的目的是评估家族性地中海热（FMF）、轴性脊柱关节炎（axSpA）以及同时患有这两种疾病（axSpA/FMF）的患者的中枢敏化（CS）水平。
本研究纳入了30例FMF患者、30例axSpA患者、30例axSpA/FMF患者以及30名健康对照者（HCs）。通过中枢敏化量表（CSI）问卷调查CS的存在情况。为了评估CS对患者组的影响，对临床特征、疾病活动度、生活质量、睡眠质量、抑郁和焦虑频率进行了检查。根据CS的存在情况和严重程度将患者分组，并比较他们的结果。
所有参与者的平均年龄为28.4±5.7岁，其中67例（55.8%）为男性。axSpA组和axSpA/FMF组的红细胞沉降率（ESR）值显著高于FMF组和HCs组（p<0.001）。FMF组的ESR值显著高于HCs组（p<0.001）。axSpA/FMF组的C反应蛋白（CRP）值显著高于axSpA组和HCs组（p=0.001）。axSpA组、FMF组和axSpA/FMF组的CSI-A部分值显著高于HCs组（p<0.001）。axSpA/FMF组、axSpA组和FMF组之间的CSI-A部分值差异不显著（p>0.05）。发现FMF组慢性疲劳综合征的发生率显著高于axSpA组和HCs组（p<0.05）。axSpA/FMF组纤维肌痛综合征的发生率显著高于axSpA组、FMF组和HCs组（p<0.05）。
在本研究中，发现axSpA和FMF患者的CS评分显著高于HCs组。疾病组之间的CS评分没有差异。
