[Ultrasound biomicroscopic differences between fellow eyes of acute angle-closure glaucoma and chronic angle-closure glaucoma].

To compare the structural differences of the anterior segment between fellow eyes of acute angle-closure glaucoma (AACG) and the eyes of chronic angle-closure glaucoma (CACG) with milder glaucomatous damage. In this case-control study, patients with AACG (41 eyes) and CACG (46 eyes) without prior treatment in the glaucoma clinic of Peking University People's Hospital from September 2016 to October 2018 were enrolled. Ultrasound biomicroscopy was performed under dark condition. Parameters were measured on images including lens vault (LV), anterior chamber depth (ACD), iris thickness (IT750 and IT2000), angle-opening distance (AOD500 and AOD750), and trabecular iris angle (TIA500 and TIA750). The independent -test was used to compare the continuous variables of the fellow eyes of AACG patients and the eyes of CACG patients with milder glaucomatous damage. After adjusting for age and gender, univariate and multivariate logistic regression analyses were performed to explore the most important parameters that may distinguish AACG from CACG. The mean age of AACG patients was (65±10) years old and the age of CACG patients was (67±12) years old (>0.05). The ACD [(1.79±0.25) mm . (1.99±0.34) mm], IT750 [(0.39±0.07) mm . (0.43±0.05) mm], AOD500 [(0.12±0.06) mm . (0.15±0.07) mm], TIA500 (10.91°±5.23° . 13.93°±6.33°), and TIA750 (9.33°±5.02° . 13.93°±6.82°) were less and the LV [(0.99±0.44) mm . (0.72±0.30) mm] was greater in the fellow eyes of AACG as compared to the eyes of CACG with milder glaucomatous damage (all <0.05). In the forward multivariate logistic regression analysis, every 1-degree decrease in TIA750 (odds ratio=0.872, 95%: 0.794 to 0.958, <0.01) and every 1-mm increase in LV (odds ratio=14.138, 95%: 2.348 to 85.130, <0.01) were significantly associated with AACG. Compared with the eyes of CACG with milder glaucomatous damage, fellow eyes of AACG have thinner peripheral iris thickness, narrower angle width, shallower ACD, and greater LV. LV and TIA750 may play important roles in distinguishing eyes predisposed to AACG or CACG. .