Chemical synthesis of saponins: An update.

Saponins, as secondary metabolites in terrestrial plants and marine invertebrate, constitute one of the largest families of natural products. The long history of folk medicinal applications of saponins makes them attractive candidates for innovative drug design and development. Chemical synthesis has become a practical alternative to the availability of the natural saponins and their modified analogs, so as to facilitate SAR studies and the discovery of optimal structures for clinical applications. The recent achievements in the synthesis of these complex saponins reflect the advancements of both steroid/triterpene chemistry and carbohydrate chemistry. This chapter provides an updated review on the chemical synthesis of natural saponins, covering the literature from 2014 to 2020.