School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Adv Carbohydr Chem Biochem. 2021;79:1-62. doi: 10.1016/bs.accb.2021.11.001. Epub 2021 Nov 25.
Saponins, as secondary metabolites in terrestrial plants and marine invertebrate, constitute one of the largest families of natural products. The long history of folk medicinal applications of saponins makes them attractive candidates for innovative drug design and development. Chemical synthesis has become a practical alternative to the availability of the natural saponins and their modified analogs, so as to facilitate SAR studies and the discovery of optimal structures for clinical applications. The recent achievements in the synthesis of these complex saponins reflect the advancements of both steroid/triterpene chemistry and carbohydrate chemistry. This chapter provides an updated review on the chemical synthesis of natural saponins, covering the literature from 2014 to 2020.
甾体皂苷和三萜皂苷是陆地植物和海洋无脊椎动物中的次生代谢产物，构成了天然产物中最大的家族之一。由于皂苷在民间医学应用方面的悠久历史，它们成为创新药物设计和开发的有吸引力的候选物。化学合成已成为获得天然皂苷及其修饰类似物的一种实用替代方法，以便促进 SAR 研究和发现用于临床应用的最佳结构。这些复杂皂苷的合成方面的最新进展反映了甾体/三萜化学和碳水化合物化学的进步。本章提供了天然皂苷化学合成的最新综述，涵盖了 2014 年至 2020 年的文献。
