Marantz P R, Linzer M
Am J Med. 1986 May;80(5):951-3. doi: 10.1016/0002-9343(86)90643-1.
Diffuse lymphadenopathy has not been previously described in association with ankylosing spondylitis. A 22-year-old man who presented with anorexia, weight loss, shoulder pain, and diffuse lymphadenopathy is described. Lymph node biopsy showed a nonspecific pattern of reactive hyperplasia with sinus histiocytosis. Clinical evaluation disclosed active spondylitis with HLA-B27 positivity. No other cause for the lymphadenopathy was found. The association between lymphadenopathy and connective tissue diseases is discussed. Ankylosing spondylitis should be added to the differential diagnosis of patients with generalized lymphadenopathy of uncertain cause.
弥漫性淋巴结病此前尚未见与强直性脊柱炎相关的报道。本文描述了一名22岁男性，该患者出现厌食、体重减轻、肩部疼痛和弥漫性淋巴结病。淋巴结活检显示为伴有窦组织细胞增生的非特异性反应性增生模式。临床评估发现为活动性脊柱炎且HLA - B27阳性。未发现导致淋巴结病的其他原因。本文讨论了淋巴结病与结缔组织病之间的关联。对于病因不明的全身性淋巴结病患者，强直性脊柱炎应纳入鉴别诊断。
