急性前葡萄膜炎、强直性脊柱炎、背痛与HLA - B27
Acute anterior uveitis, ankylosing spondylitis, back pain, and HLA-B27.
作者信息
Beckingsale A B, Davies J, Gibson J M, Rosenthal A R
出版信息
Br J Ophthalmol. 1984 Oct;68(10):741-5. doi: 10.1136/bjo.68.10.741.
One hundred and sixty-nine patients with acute anterior uveitis were studied for the presence of HLA-B27 tissue type, radiological evidence of ankylosing spondylitis, and a history of back pain. 60% were male; 45% were HLA-B27+. The male:female ratio in the HLA-B27+ group was the same as in the whole group. 24% had radiological evidence of ankylosing spondylitis, and, of these, 83% were HLA-B27+ while 17% were HLA-B27-. There was a definite correlation between the severity of the ankylosing spondylitis and preponderance of males in the HLA-B27+ group of patients. Significant back pain occurred in 60% of HLA-B27+ patients but in only 14% of HLA-B27- patients. The importance of the selection of patients and of consistency in the use of diagnostic criteria in studies relating to ankylosing spondylitis and acute anterior uveitis is stressed.
对169例急性前葡萄膜炎患者进行了研究，以确定其HLA - B27组织类型、强直性脊柱炎的放射学证据以及背痛病史。60%为男性；45%为HLA - B27阳性。HLA - B27阳性组的男女比例与整个研究组相同。24%有强直性脊柱炎的放射学证据，其中83%为HLA - B27阳性，17%为HLA - B27阴性。在HLA - B27阳性患者组中，强直性脊柱炎的严重程度与男性占优势之间存在明确的相关性。60%的HLA - B27阳性患者有明显背痛，而HLA - B27阴性患者中只有14%有明显背痛。强调了在与强直性脊柱炎和急性前葡萄膜炎相关的研究中患者选择和诊断标准使用一致性的重要性。
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