Shih S T, Khorram O, Lipton J M, McCann S M
Am J Physiol. 1986 May;250(5 Pt 2):R803-6. doi: 10.1152/ajpregu.1986.250.5.R803.
alpha-Melanocyte-stimulating hormone (alpha-MSH) has a marked antipyretic action when given centrally or peripherally, and the concentration of this peptide within the septal region of the brain increases during fever. To assess the significance of endogenous central alpha-MSH in fever, antiserum was given to rabbits via a cannula implanted in the third cerebral ventricle. Each day for 3 days, the animals received 50 microliters of normal rabbit serum (NRS) or an equal volume of antiserum raised against alpha-MSH. Interleukin 1 (IL 1) was then injected intravenously to determine the effect of central immunoneutralization of alpha-MSH on the febrile response. Immunoneutralization markedly prolonged fever. The average rise in temperature and the area under the fever curve after IL 1 injection were also significantly increased. Antiserum treatment did not alter normal body temperature, and NRS had no effect on IL 1-induced fever. These results indicate that endogenous central alpha-MSH contributes to physiological limitation of fever and that the role of this peptide in temperature regulation is relevant to the febrile state but not to normothermia.
α-黑素细胞刺激素（α-MSH）经中枢或外周给予时具有显著的解热作用，且发热期间脑隔区该肽的浓度会升高。为评估内源性中枢α-MSH在发热中的意义，通过植入第三脑室的套管给兔子注射抗血清。连续3天，每天给动物注射50微升正常兔血清（NRS）或等量针对α-MSH产生的抗血清。然后静脉注射白细胞介素1（IL-1），以确定α-MSH的中枢免疫中和对发热反应的影响。免疫中和显著延长了发热时间。IL-1注射后体温的平均升高幅度和发热曲线下面积也显著增加。抗血清治疗未改变正常体温，NRS对IL-1诱导的发热无影响。这些结果表明，内源性中枢α-MSH有助于对发热进行生理限制，且该肽在体温调节中的作用与发热状态相关，而与正常体温无关。
