Comparative antibacterial activity of an arylglycyl oral cephalosporin, LY164846.
作者信息
Chin N X, Neu H C
出版信息
Antimicrob Agents Chemother. 1986 Apr;29(4):703-6. doi: 10.1128/AAC.29.4.703.
Abstract
LY164846 is a semisynthetic arylglycyl cephalosporin which can be absorbed orally. It had in vitro activity comparable to that of cefaclor against beta-hemolytic streptococcal species and was two- to fourfold more active than cephalexin. Enterococci and Listeria species were resistant, and its activity against staphylococci was similar to that of other oral cephalosporins. Although some Bacteroides species were inhibited, the MICs for 25% were greater than or equal to 16 micrograms/ml. LY164846 was hydrolyzed by Staphylococcus aureus beta-lactamase and by cephalosporinases, but it was more stable than cefaclor.
摘要
相似文献
1
Comparative antibacterial activity of an arylglycyl oral cephalosporin, LY164846.
Antimicrob Agents Chemother. 1986 Apr;29(4):703-6. doi: 10.1128/AAC.29.4.703.
2
In vitro activity of an orally administered cephalosporin, LY164846, against potentially pathogenic respiratory and dermal bacterial isolates.
Antimicrob Agents Chemother. 1986 Apr;29(4):560-4. doi: 10.1128/AAC.29.4.560.
3
Antibacterial activity and beta-lactamase stability of MDL 19,592, an oral cephalosporin.
Diagn Microbiol Infect Dis. 1989 Sep-Oct;12(5):441-3. doi: 10.1016/0732-8893(89)90117-x.
4
BMY-28100, a new oral cephalosporin: antimicrobial activity against nearly 7,000 recent clinical isolates, comparative potency with other oral agents, and activity against beta-lactamase producing isolates.
Diagn Microbiol Infect Dis. 1988 Jan;9(1):11-26. doi: 10.1016/0732-8893(88)90056-9.
5
Comparative antibacterial activity of a new oral cephalosporin, BMY-28100.
Antimicrob Agents Chemother. 1987 Mar;31(3):480-3. doi: 10.1128/AAC.31.3.480.
6
Comparative in vitro activity and beta-lactamase stability of FR 17027, a new orally active cephalosporin.
Antimicrob Agents Chemother. 1984 Aug;26(2):174-80. doi: 10.1128/AAC.26.2.174.
7
In vitro activity of an oral iminomethoxy aminothiazolyl cephalosporin, R-3746.
Antimicrob Agents Chemother. 1988 May;32(5):671-7. doi: 10.1128/AAC.32.5.671.
8
In vitro activity of cefcanel versus other oral cephalosporins.
Eur J Clin Microbiol Infect Dis. 1991 Aug;10(8):676-82. doi: 10.1007/BF01975825.
9
Comparative in vitro activity and beta-lactamase stability of FK482, a new oral cephalosporin.
Antimicrob Agents Chemother. 1989 Oct;33(10):1795-800. doi: 10.1128/AAC.33.10.1795.
10
Antimicrobial activity and beta-lactamase stability of BMY-28232, parent compound of an oral cephalosporin.
Eur J Clin Microbiol Infect Dis. 1990 Nov;9(11):841-6. doi: 10.1007/BF01967389.
引用本文的文献
1
beta-Lactamase stability and in vitro activity of oral cephalosporins against strains possessing well-characterized mechanisms of resistance.
Antimicrob Agents Chemother. 1989 Aug;33(8):1313-7. doi: 10.1128/AAC.33.8.1313.
本文引用的文献
1
Susceptibility of respiratory tract anaerobes to orally administered penicillins and cephalosporins.
Antimicrob Agents Chemother. 1976 Oct;10(4):713-20. doi: 10.1128/AAC.10.4.713.
2
In vitro activities of five oral cephalosporins against aerobic pathogenic bacteria.
Antimicrob Agents Chemother. 1977 Nov;12(5):609-13. doi: 10.1128/AAC.12.5.609.
3
In vitro studies with cefaclor, a new oral cephalosporin.
Antimicrob Agents Chemother. 1977 Oct;12(4):490-7. doi: 10.1128/AAC.12.4.490.
4
Cefaclor: in vitro spectrum of activity and beta-lactamase stability.
Antimicrob Agents Chemother. 1978 Apr;13(4):584-8. doi: 10.1128/AAC.13.4.584.
5
Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.
Antimicrob Agents Chemother. 1977 Mar;11(3):470-4. doi: 10.1128/AAC.11.3.470.
Zotero 插件