头孢氨苄、头孢拉定和头孢克洛的体外活性比较。
Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.
作者信息
Bill N J, Washington J A
出版信息
Antimicrob Agents Chemother. 1977 Mar;11(3):470-4. doi: 10.1128/AAC.11.3.470.
Abstract
Inhibitory activity of cephalexin, cephradine, and cefaclor was compared by the WHO-ICS agar dilution technique. Cefaclor was substantially more active against staphylococci, streptococci, gonococci, meningococci, Haemophilus, Escherichia coli, Klebsiella pneumoniae, Citrobacter diversus, Proteus mirabilis, salmonellae, and shigellae than was cephalexin, which in turn was more active than cephradine. Cefaclor appeared to be less resistant to staphylococcal penicillinase than did the other two agents. None of these cephalosporins was active against Enterobacter, Serratia, indole-positive Proteeae, Pseudomonas, or Bacteroides fragilis.
摘要
采用世界卫生组织国际化学学会琼脂稀释技术比较了头孢氨苄、头孢拉定和头孢克洛的抑制活性。与头孢氨苄相比，头孢克洛对葡萄球菌、链球菌、淋球菌、脑膜炎球菌、嗜血杆菌、大肠杆菌、肺炎克雷伯菌、奇异变形杆菌、沙门氏菌和志贺氏菌的活性要强得多，而头孢氨苄的活性又比头孢拉定强。头孢克洛似乎比其他两种药物对葡萄球菌青霉素酶的耐药性更低。这些头孢菌素对肠杆菌、沙雷氏菌、吲哚阳性变形杆菌、假单胞菌或脆弱拟杆菌均无活性。
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