头孢克洛：体外活性谱及β-内酰胺酶稳定性
Cefaclor: in vitro spectrum of activity and beta-lactamase stability.
作者信息
Neu H C, Fu K P
出版信息
Antimicrob Agents Chemother. 1978 Apr;13(4):584-8. doi: 10.1128/AAC.13.4.584.
Abstract
The in vitro activity of cefaclor against 556 clinical isolates of gram-positive and gram-negative bacteria was compared with that of other cephalosporins. Cefaclor had activity similar to that of cephalexin against gram-positive bacteria. It showed greater activity against Haemophilus strains than did cephalexin and inhibited beta-lactamase-producing Haemophilus isolates. Cefaclor was more active than cephalexin or cephalothin against Escherichia coli, Salmonella, and Shigella isolates but did not act against Serratia, Acinetobacter, indole-positive Proteus, or Bacteroides isolates. Cefaclor was resistant to type III (TEM) beta-lactamases but was destroyed by type I beta-lactamases and, to a lesser degree, by type IV and type V beta-lactamases.
摘要
将头孢克洛对556株革兰氏阳性和革兰氏阴性细菌临床分离株的体外活性与其他头孢菌素进行了比较。头孢克洛对革兰氏阳性菌的活性与头孢氨苄相似。它对嗜血杆菌菌株的活性比头孢氨苄更强，并能抑制产β-内酰胺酶的嗜血杆菌分离株。头孢克洛对大肠杆菌、沙门氏菌和志贺氏菌分离株的活性比头孢氨苄或头孢噻吩更强，但对沙雷氏菌、不动杆菌、吲哚阳性变形杆菌或拟杆菌分离株无作用。头孢克洛对III型（TEM）β-内酰胺酶具有抗性，但被I型β-内酰胺酶破坏，在较小程度上也被IV型和V型β-内酰胺酶破坏。
相似文献
1
Cefaclor: in vitro spectrum of activity and beta-lactamase stability.头孢克洛：体外活性谱及β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1978 Apr;13(4):584-8. doi: 10.1128/AAC.13.4.584.
2
In vitro activity and beta-lactamase stability of BL-S786 compared with those of other cephalosporins.BL-S786与其他头孢菌素相比的体外活性及β-内酰胺酶稳定性。
Antimicrob Agents Chemother. 1978 Jul;14(1):1-5. doi: 10.1128/AAC.14.1.1.
3
Cefuroxime, a beta-lactamase-resistant cephalosporin with a broad spectrum of gram-positive and -negative activity.头孢呋辛，一种对β-内酰胺酶稳定的头孢菌素，具有广谱的革兰氏阳性和阴性菌活性。
Antimicrob Agents Chemother. 1978 Apr;13(4):657-64. doi: 10.1128/AAC.13.4.657.
4
In vitro activity and beta-lactamase stability of cefazaflur compared with those of beta-lactamase-stable cephalosporins.头孢扎氟的体外活性及β-内酰胺酶稳定性与β-内酰胺酶稳定型头孢菌素的比较。
Antimicrob Agents Chemother. 1979 Mar;15(3):444-6. doi: 10.1128/AAC.15.3.444.
5
In vitro activity and beta-lactamase stability of LY163892.LY163892的体外活性及β-内酰胺酶稳定性
Eur J Clin Microbiol Infect Dis. 1988 Aug;7(4):549-51. doi: 10.1007/BF01962613.
6
Comparative study of seven cephalosporins: susceptibility to beta-lactamases and ability to penetrate the surface layers of Escherichia coli.七种头孢菌素的比较研究：对β-内酰胺酶的敏感性及穿透大肠杆菌表层的能力
Antimicrob Agents Chemother. 1976 Aug;10(2):219-22. doi: 10.1128/AAC.10.2.219.
7
BMY-28100, a new oral cephalosporin: antimicrobial activity against nearly 7,000 recent clinical isolates, comparative potency with other oral agents, and activity against beta-lactamase producing isolates.新型口服头孢菌素BMY-28100：对近7000株近期临床分离菌株的抗菌活性、与其他口服制剂的相对效价以及对产β-内酰胺酶分离菌株的活性
Diagn Microbiol Infect Dis. 1988 Jan;9(1):11-26. doi: 10.1016/0732-8893(88)90056-9.
8
In vitro activity of an oral iminomethoxy aminothiazolyl cephalosporin, R-3746.口服亚胺甲氧基氨噻唑基头孢菌素R-3746的体外活性
Antimicrob Agents Chemother. 1988 May;32(5):671-7. doi: 10.1128/AAC.32.5.671.
9
The activity and beta-lactamase stability of cefotetan compared to other beta-lactam antibiotics.与其他β-内酰胺类抗生素相比，头孢替坦的活性及β-内酰胺酶稳定性。
Chemioterapia. 1985 Aug;4(4):271-7.
10
A comparative study of the activity of cefamandole and other cephalosporins and analysis of the beta-lactamase stability and synergy of cefamandole with aminoglycosides.头孢孟多与其他头孢菌素活性的比较研究以及头孢孟多对β-内酰胺酶的稳定性和与氨基糖苷类药物协同作用的分析。
J Infect Dis. 1978 May;137 Suppl:S38-S50. doi: 10.1093/infdis/137.supplement.s38.
引用本文的文献
1
Evaluating Effects of Antibiotics Across Preclinical Models of the Human Gastrointestinal Microbiota.评估抗生素对人类胃肠道微生物群临床前模型的影响。
Microbiologyopen. 2025 Aug;14(4):e70030. doi: 10.1002/mbo3.70030.
2
Antibiotics for emerging pathogens.针对新出现病原体的抗生素。
Science. 2009 Aug 28;325(5944):1089-93. doi: 10.1126/science.1176667.
3
Effects of prophylactic administration of cefaclor on transient bacteremia after dental extraction.头孢克洛预防性给药对拔牙后短暂菌血症的影响。
Eur J Clin Microbiol Infect Dis. 1996 Aug;15(8):646-9. doi: 10.1007/BF01691150.
4
In vitro antibacterial activity and beta-lactamase stability of SY5555, a new oral penem antibiotic.新型口服青霉烯类抗生素SY5555的体外抗菌活性及β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1994 Sep;38(9):1974-9. doi: 10.1128/AAC.38.9.1974.
5
Autobac I procedure to assess susceptibility to Cefaclor.使用自动细菌鉴定仪I法评估对头孢克洛的敏感性。
J Clin Microbiol. 1980 Jun;11(6):660-3. doi: 10.1128/jcm.11.6.660-663.1980.
6
Susceptibility of Haemophilus influenzae type b to cefaclor and influence of inoculum size.b型流感嗜血杆菌对头孢克洛的敏感性及接种量的影响。
Antimicrob Agents Chemother. 1982 Nov;22(5):923-5. doi: 10.1128/AAC.22.5.923.
7
In vitro and in vivo antibacterial properties of FK 027, a new orally active cephem antibiotic.新型口服活性头孢烯抗生素FK 027的体外和体内抗菌特性
Antimicrob Agents Chemother. 1984 Jan;25(1):98-104. doi: 10.1128/AAC.25.1.98.
8
Penetration of cefaclor into bronchial mucosa.头孢克洛在支气管黏膜中的渗透情况。
Thorax. 1984 Nov;39(11):813-7. doi: 10.1136/thx.39.11.813.
9
Cefaclor versus amoxicillin in the treatment of bacterial pneumonia: a comparative double-blind study.头孢克洛与阿莫西林治疗细菌性肺炎的比较：一项双盲对照研究。
Eur J Clin Microbiol. 1983 Feb;2(1):11-6. doi: 10.1007/BF02019916.
10
In vitro and in vivo antibacterial activities of T-2588, a new oral cephalosporin, compared with those of other oral beta-lactam antibiotics.新型口服头孢菌素T-2588与其他口服β-内酰胺类抗生素相比的体内外抗菌活性。
Antimicrob Agents Chemother. 1987 Jul;31(7):1111-6. doi: 10.1128/AAC.31.7.1111.
本文引用的文献
1
Cefamandole, a cephalosporin antibiotic with an unusually wide spectrum of activity.头孢孟多，一种具有异常广泛活性谱的头孢菌素抗生素。
Antimicrob Agents Chemother. 1974 Aug;6(2):177-82. doi: 10.1128/AAC.6.2.177.
2
Cefoxitin, a semisynthetic cephamycin antibiotic: antibacterial spectrum and resistance to hydrolysis by gram-negative beta-lactamases.头孢西丁，一种半合成头孢霉素抗生素：抗菌谱及对革兰氏阴性β-内酰胺酶水解的抗性。
Antimicrob Agents Chemother. 1974 Aug;6(2):170-6. doi: 10.1128/AAC.6.2.170.
3
Micro-iodometric assay for penicillinase.青霉素酶的微量碘量法测定
Biochem J. 1962 May;83(2):236-40. doi: 10.1042/bj0830236.
4
The beta-lactamases of gram-negative bacteria and their possible physiological role.革兰氏阴性菌的β-内酰胺酶及其可能的生理作用。
Adv Microb Physiol. 1973;9:31-88. doi: 10.1016/s0065-2911(08)60376-8.
5
Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.头孢氨苄、头孢拉定和头孢克洛的体外活性比较。
Antimicrob Agents Chemother. 1977 Mar;11(3):470-4. doi: 10.1128/AAC.11.3.470.
6
In vitro study of netilmicin compared with other aminoglycosides.奈替米星与其他氨基糖苷类药物的体外研究。
Antimicrob Agents Chemother. 1976 Sep;10(3):526-34. doi: 10.1128/AAC.10.3.526.
Zotero 插件