Wilson R F, Mammen E F, Robson M C, Heggers J P, Soullier G, DePoli P A
Arch Surg. 1986 Jun;121(6):635-40. doi: 10.1001/archsurg.1986.01400060029002.
Antithrombin (AT), prekallikrein (PK), and fibronectin (FN) levels were measured in the plasma of 290 patients. The mean (+/- SD) lowest AT level measured in 287 patients was 70% +/- 18% (normal, 75% to 120% of control). The mean lowest AT level in 81 septic patients (49% +/- 17%) was significantly lower than in the 206 patients without sepsis (78% +/- 22%). The mean AT level in 60 patients who died (42% +/- 22%) was significantly lower than in 227 patients who lived (78% +/- 19%). The mean lowest PK level measured in 71 patients was 42% +/- 17% (normal, 80% to 120%). The mean PK level in 32 septic patients (26% +/- 12%) was significantly lower than in 39 patients who were not septic (54% +/- 19%). The mean lowest FN level measured in 45 patients was 193 +/- 86 micrograms/mL (normal, 160 to 240 micrograms/mL). The mean FN level in 15 septic patients (128 +/- 72 micrograms/mL) was significantly lower than in the 30 nonseptic patients (266 +/- 84 micrograms/mL). Following AT, PK, and FN levels in critically ill surgical patients may allow earlier diagnosis and more effective treatment of sepsis.
在290例患者的血浆中检测了抗凝血酶（AT）、前激肽释放酶（PK）和纤连蛋白（FN）水平。287例患者测得的平均（±标准差）最低AT水平为70%±18%（正常为对照值的75%至120%）。81例脓毒症患者的平均最低AT水平（49%±17%）显著低于206例无脓毒症患者（78%±22%）。60例死亡患者的平均AT水平（42%±22%）显著低于227例存活患者（78%±19%）。71例患者测得的平均最低PK水平为42%±17%（正常为80%至120%）。32例脓毒症患者的平均PK水平（26%±12%）显著低于39例非脓毒症患者（54%±19%）。45例患者测得的平均最低FN水平为193±86微克/毫升（正常为160至240微克/毫升）。15例脓毒症患者的平均FN水平（128±72微克/毫升）显著低于30例非脓毒症患者（266±84微克/毫升）。监测重症外科患者的AT、PK和FN水平可能有助于脓毒症的早期诊断和更有效的治疗。
