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环糊精金属有机骨架作为疫苗佐剂增强免疫应答。

Cyclodextrin metal-organic framework as vaccine adjuvants enhances immune responses.

机构信息

College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu, China.

Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Chengdu, China.

出版信息

Drug Deliv. 2021 Dec;28(1):2594-2602. doi: 10.1080/10717544.2021.2012306.

DOI:10.1080/10717544.2021.2012306
PMID:34866536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8741229/
Abstract

It is urgently needed to develop novel adjuvants for improving the safety and efficacy of vaccines. Metal-organic frameworks (MOFs), with high surface area, play an important role in drug delivery. With perfect biocompatibility and green preparation process, the γ-cyclodextrin metal-organic framework (γ-CD-MOF) fabricated with cyclodextrin and potassium suitable for antigen delivery. In this study, we modified γ-CD-MOF with span-85 to fabricate the SP-γ-CD-MOF as animal vaccine adjuvants. The ovalbumin (OVA) as the model antigen was encapsulated into particles to investigate the immune response. SP-γ-CD-MOF displayed excellent biocompatibility and . After immunization, SP-γ-CD-MOF loaded with OVA could induce high antigen-specific IgG titers and cytokine secretion. Meanwhile, SP-γ-CD-MOF also significantly improved the proliferation of spleen cells and activated and matured the bone marrow dendritic cells (BMDCs). The study showed the potential of SP-γ-CD-MOF in vaccine adjuvants and provided a novel idea for the development of vaccine adjuvants.

摘要

迫切需要开发新型佐剂来提高疫苗的安全性和疗效。金属-有机骨架（MOFs）具有高表面积，在药物传递中发挥重要作用。γ-环糊精金属-有机骨架（γ-CD-MOF）由环糊精和钾制成，具有完美的生物相容性和绿色制备工艺，适合抗原传递。在这项研究中，我们用 Span-85 修饰 γ-CD-MOF 作为动物疫苗佐剂。以卵清蛋白（OVA）作为模型抗原包封在颗粒中，以研究免疫反应。SP-γ-CD-MOF 表现出优异的生物相容性和。免疫后，负载 OVA 的 SP-γ-CD-MOF 可诱导高抗原特异性 IgG 滴度和细胞因子分泌。同时，SP-γ-CD-MOF 还显著促进了脾细胞的增殖，并激活和成熟了骨髓树突状细胞（BMDCs）。该研究显示了 SP-γ-CD-MOF 在疫苗佐剂中的潜力，并为疫苗佐剂的开发提供了新的思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/e7e40802e3de/IDRD_A_2012306_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/e5bc7505e9be/IDRD_A_2012306_SCH0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/75e99f2ed5fa/IDRD_A_2012306_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/70260f247c10/IDRD_A_2012306_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/fe160118a70b/IDRD_A_2012306_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/49dfd0b4cce2/IDRD_A_2012306_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/db15d97629a5/IDRD_A_2012306_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/4fb519a2a358/IDRD_A_2012306_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/f279d725363f/IDRD_A_2012306_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/e7e40802e3de/IDRD_A_2012306_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/e5bc7505e9be/IDRD_A_2012306_SCH0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/75e99f2ed5fa/IDRD_A_2012306_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/70260f247c10/IDRD_A_2012306_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/fe160118a70b/IDRD_A_2012306_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/49dfd0b4cce2/IDRD_A_2012306_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/db15d97629a5/IDRD_A_2012306_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/4fb519a2a358/IDRD_A_2012306_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/f279d725363f/IDRD_A_2012306_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/044a/8741229/e7e40802e3de/IDRD_A_2012306_F0008_C.jpg

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