College of Animal Science and Veterinary Medicine, Southwest Minzu University, Chengdu, China.
College of Chemistry & Environment, Southwest Minzu University, Chengdu, China.
Drug Deliv. 2021 Dec;28(1):372-379. doi: 10.1080/10717544.2021.1879316.
We presented an antibiotic-loaded γ-cyclodextrin metal-organic framework that delivered antibiotics suitable for the treatment of bacterial infections. The γ-cyclodextrin metal-organic framework was developed using γ-cyclodextrin and potassium ion via the ultrasonic method. The antibiotic (florfenicol and enrofloxacin) was primarily encapsulated into the pore structures of γ-CD-MOF, which allowed the sustained release of antibiotics over an extended period of time and . Notably, antibiotics-loaded γ-CD-MOF showed much superior activity against bacteria than free antibiotics (lower MIC value) and displayed better long-lasting activity (longer antibacterial time). The antibiotics-loaded γ-CD-MOF showed nontoxic and perfect biocompatibility to mammalian cells and tissues both and . These materials thus represent a novel drug-delivery device suitable for antibiotic therapy. This research is of great significance for reducing the generation of bacterial resistance and providing new ideas for the application of γ-CD-MOF.
我们提出了一种载抗生素的 γ-环糊精金属有机骨架，可提供适合治疗细菌感染的抗生素。γ-环糊精金属有机骨架是通过超声法用 γ-环糊精和钾离子合成的。抗生素（氟苯尼考和恩诺沙星）主要被包封在γ-CD-MOF 的孔结构中，这使得抗生素能够在较长时间内持续释放。值得注意的是，载抗生素的 γ-CD-MOF 对细菌的活性明显优于游离抗生素（更低的 MIC 值），并表现出更好的长效活性（更长的抗菌时间）。载抗生素的 γ-CD-MOF 对哺乳动物细胞和组织表现出非毒性和完美的生物相容性。这些材料因此代表了一种适合抗生素治疗的新型药物输送装置。这项研究对于减少细菌耐药性的产生具有重要意义，为 γ-CD-MOF 的应用提供了新的思路。
