Sure Matthias, Vesper Jan, Schnitzler Alfons, Florin Esther
Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Department of Functional Neurosurgery and Stereotaxy, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany.
Front Neurosci. 2021 Nov 11;15:724334. doi: 10.3389/fnins.2021.724334. eCollection 2021.
In Parkinson's disease (PD), subthalamic nucleus (STN) beta burst activity is pathologically elevated. These bursts are reduced by dopamine and deep brain stimulation (DBS). Therefore, these bursts have been tested as a trigger for closed-loop DBS. To provide better targeted parameters for closed-loop stimulation, we investigate the spatial distribution of beta bursts within the STN and if they are specific to a beta sub-band. Local field potentials (LFP) were acquired in the STN of 27 PD patients while resting. Based on the orientation of segmented DBS electrodes, the LFPs were classified as anterior, postero-medial, and postero-lateral. Each recording lasted 30 min with (ON) and without (OFF) dopamine. Bursts were detected in three frequency bands: ±3 Hz around the individual beta peak frequency, low beta band (lBB), and high beta band (hBB). Medication reduced the duration and the number of bursts per minute but not the amplitude of the beta bursts. The burst amplitude was spatially modulated, while the burst duration and rate were frequency dependent. Furthermore, the hBB burst duration was positively correlated with the akinetic-rigid UPDRS III subscore. Overall, these findings on differential dopaminergic modulation of beta burst parameters suggest that hBB burst duration is a promising target for closed-loop stimulation and that burst parameters could guide DBS programming.
在帕金森病（PD）中，丘脑底核（STN）的β波爆发活动在病理上有所升高。多巴胺和深部脑刺激（DBS）可减少这些爆发。因此，这些爆发已被测试作为闭环DBS的触发因素。为了为闭环刺激提供更好的靶向参数，我们研究了STN内β波爆发的空间分布以及它们是否特定于β子频段。在27名PD患者休息时采集其STN的局部场电位（LFP）。根据分段DBS电极的方向，将LFP分为前部、后内侧和后外侧。每次记录持续30分钟，记录时多巴胺存在（ON）和不存在（OFF）的情况。在三个频段检测到爆发：在个体β峰值频率周围±3Hz、低β频段（lBB）和高β频段（hBB）。药物治疗减少了爆发的持续时间和每分钟的爆发次数，但没有降低β波爆发的幅度。爆发幅度在空间上受到调制，而爆发持续时间和频率则与频率有关。此外，hBB爆发持续时间与运动不能-强直UPDRS III子评分呈正相关。总体而言，这些关于β波爆发参数的多巴胺能差异调制的发现表明，hBB爆发持续时间是闭环刺激的一个有前景的靶点，并且爆发参数可以指导DBS编程。
