Chen Bangjie, Rao Xianyue, Wang Xinyi, Luo Zhipan, Wang Jianpeng, Sheng Shuyan, Liu Yuchen, Zhang Ning, Jin Shiyu, Chen Haosong, Sun Chenyu, Xu Tao, Du Yingying
The First Affiliated Hospital of Anhui Medical University, Hefei, China.
First Clinical Medical College, Anhui Medical University, Heifei, China.
Front Pharmacol. 2021 Aug 18;12:719644. doi: 10.3389/fphar.2021.719644. eCollection 2021.
The cGAS-STING signaling pathway is an autoimmune inflammatory pathway that can trigger the expression of a series of inflammatory factors represented by type 1 interferon. Recent studies have found that the cGAS-STING signaling pathway played a significant role in liver physiology and was closely related to the progress of liver diseases. For example, activating the cGAS-STING signaling pathway could significantly inhibit hepatitis B virus (HBV) replication in vivo. Moreover, the cGAS-STING signaling pathway was also closely associated with tumor immunity in hepatocellular carcinoma (HCC). This review summarized the role of the cGAS-STING signaling pathway in several common liver diseases, especially the current application of the cGAS-STING signaling pathway in liver disease treatment, and prospected its future research, which provided a new idea for understanding and treating liver diseases.
cGAS-STING信号通路是一条自身免疫炎症通路，可触发以1型干扰素为代表的一系列炎症因子的表达。最近的研究发现，cGAS-STING信号通路在肝脏生理过程中发挥着重要作用，且与肝脏疾病的进展密切相关。例如，激活cGAS-STING信号通路可在体内显著抑制乙型肝炎病毒（HBV）复制。此外，cGAS-STING信号通路还与肝细胞癌（HCC）的肿瘤免疫密切相关。本综述总结了cGAS-STING信号通路在几种常见肝脏疾病中的作用，尤其是cGAS-STING信号通路在肝脏疾病治疗中的当前应用，并对其未来研究进行了展望，为理解和治疗肝脏疾病提供了新思路。
