Pastushkova L K, Rusanov V B, Goncharova A G, Nosovsky A M, Kashirina D N, Kireev K S, Larina I M
Institute of Biomedical Problems of RAS, 76A Khoroshevskoe shosse, Moscow 123007, Russian Federation, e-mail:
Gagarin Research & Test Cosmonaut Training Center, Star City, Moscow region 141160, Russian Federation.
Adv Gerontol. 2022;35(6):869-876.
As the life of the International Space Station (ISS) is lengthening, Russian crews are dominated by cosmonauts over 40 years of age who have repeatedly made a space flight (SF) and have a long stay on the ISS. In order to study the age-related features of the regulation of heart rate variability (HRV) in cosmonauts, based on proteomics data, we analyzed simultaneously the obtained data on the proteomic composition of urine samples and electrocardiogram (ECG) parameters, followed by an analysis of heart rate variability (HRV) in cosmonauts in the age group of 46,5±3,4 (n=12). The survey was carried out in the period of preparation for the next flight. The urine proteome was studied by mass spectrometry and analyzed by bioinformatic methods. Heart rate variability was assessed by software methods for analyzing ECG fragments. For the first time, data based on proteomics on the age-related features of the regulation of heart rate variability in cosmonauts are presented. According to age periodization, cosmonauts are in the middle age of the second period. The concentrations of mucin 1, type VI collagen, and cadherin 13 were shown to change with age. A decrease in HRV was also observed with increasing age. There was an increase in sympathetic influence and a progressive decrease in parasympathetic influence.
随着国际空间站（ISS）寿命的延长，俄罗斯机组人员主要由40岁以上的宇航员组成，他们多次进行太空飞行（SF）并在国际空间站长期停留。为了研究宇航员心率变异性（HRV）调节的年龄相关特征，基于蛋白质组学数据，我们同时分析了尿液样本蛋白质组组成和心电图（ECG）参数的所得数据，随后对年龄在46.5±3.4岁（n = 12）的宇航员的心率变异性（HRV）进行了分析。该调查在为下一次飞行做准备期间进行。通过质谱法研究尿液蛋白质组，并通过生物信息学方法进行分析。通过软件方法分析心电图片段来评估心率变异性。首次呈现了基于蛋白质组学的宇航员心率变异性调节年龄相关特征的数据。根据年龄分期，宇航员处于第二个时期的中年。已表明粘蛋白1、VI型胶原蛋白和钙粘蛋白13的浓度随年龄变化。随着年龄增长还观察到HRV降低。交感神经影响增加，副交感神经影响逐渐降低。
