Vishnubhotla Ramana V, Radhakrishnan Rupa, Kveraga Kestas, Deardorff Rachael, Ram Chithra, Pawale Dhanashri, Wu Yu-Chien, Renschler Janelle, Subramaniam Balachundhar, Sadhasivam Senthilkumar
Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States.
Department of Anesthesia, Critical Care and Pain Medicine, Sadhguru Center for a Conscious Planet, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Front Psychol. 2021 Nov 18;12:745344. doi: 10.3389/fpsyg.2021.745344. eCollection 2021.
The purpose of this study was to investigate the effect of an intensive 8-day Samyama meditation program on the brain functional connectivity using resting-state functional MRI (rs-fMRI). Thirteen Samyama program participants (meditators) and 4 controls underwent fMRI brain scans before and after the 8-day residential meditation program. Subjects underwent fMRI with a blood oxygen level dependent (BOLD) contrast at rest and during focused breathing. Changes in network connectivity before and after Samyama program were evaluated. In addition, validated psychological metrics were correlated with changes in functional connectivity. Meditators showed significantly increased network connectivity between the salience network (SN) and default mode network (DMN) after the Samyama program ( < 0.01). Increased connectivity within the SN correlated with an improvement in self-reported mindfulness scores ( < 0.01). Samyama, an intensive silent meditation program, favorably increased the resting-state functional connectivity between the salience and default mode networks. During focused breath watching, meditators had lower intra-network connectivity in specific networks. Furthermore, increased intra-network connectivity correlated with improved self-reported mindfulness after Samyama. [https://clinicaltrials.gov], Identifier: [NCT04366544]. Registered on 4/17/2020.
本研究的目的是使用静息态功能磁共振成像（rs-fMRI）来研究为期8天的深度三摩地冥想课程对大脑功能连接性的影响。13名参加三摩地课程的参与者（冥想者）和4名对照组人员在为期8天的住宿式冥想课程前后接受了功能磁共振成像脑部扫描。受试者在静息状态和专注呼吸期间接受了基于血氧水平依赖（BOLD）对比的功能磁共振成像检查。评估了三摩地课程前后网络连接性的变化。此外，将经过验证的心理指标与功能连接性的变化进行了关联分析。冥想者在完成三摩地课程后，突显网络（SN）和默认模式网络（DMN）之间的网络连接性显著增加（<0.01）。突显网络内连接性的增加与自我报告的正念分数的改善相关（<0.01）。三摩地，一项深度的静默冥想课程，有利地增加了突显网络和默认模式网络之间的静息态功能连接性。在专注观察呼吸期间，冥想者在特定网络中的网络内连接性较低。此外，网络内连接性的增加与三摩地课程后自我报告的正念改善相关。[https://clinicaltrials.gov]，标识符：[NCT04366544]。于2020年4月17日注册。
