糖化血红蛋白 A1c 水平与突发性聋的相关性：一项前瞻性研究。
Association of Glycosylated Hemoglobin A1c Level With Sudden Sensorineural Hearing Loss: A Prospective Study.
机构信息
Department of Otolaryngology Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China.
出版信息
Front Endocrinol (Lausanne). 2021 Nov 18;12:763021. doi: 10.3389/fendo.2021.763021. eCollection 2021.
Glycosylated hemoglobin A1c (HbA1c) level has strong relevance to microvascular disorders, which are also thought to be the current main aspect of sudden sensorineural hearing loss (SSNHL), so we aim to elucidate the association of the HbA1c level with the severity, types, and prognosis of SSNHL. In this study, comparative analyses based on propensity score matching of the severity, types, and prognosis of SSNHL with the HbA1c level in 116 patients diagnosed as SSNHL were conducted, where they were divided into diabetes mellitus (DM) group and non-DM group. We finally found that, among patients with SSNHL, diabetic patients had a higher HbA1c level, more severe hearing loss, and poorer prognosis than non-diabetic patients. The HbA1c level was found to be significantly correlated with the severity and types of SSNHL, while no strong relevance was found between the higher HbA1c level and the poorer prognosis of SSNHL.
糖化血红蛋白 A1c（HbA1c）水平与微血管疾病密切相关，而微血管疾病也被认为是突发性聋（SSNHL）的主要发病机制之一。因此，本研究旨在阐明 HbA1c 水平与 SSNHL 的严重程度、类型和预后的关系。本研究对 116 例 SSNHL 患者进行了基于倾向评分匹配的严重程度、类型和预后的比较分析，根据是否患有糖尿病（DM）将其分为 DM 组和非 DM 组。结果发现，与非糖尿病患者相比，糖尿病患者的 HbA1c 水平更高，听力损失更严重，预后更差。HbA1c 水平与 SSNHL 的严重程度和类型显著相关，而与 SSNHL 的预后不良无明显相关性。
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