Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Front Immunol. 2021 Nov 19;12:765044. doi: 10.3389/fimmu.2021.765044. eCollection 2021.
B cells are well known as key mediators of humoral immune responses the production of antibodies. Immunoglobulin A (IgA) is the most abundantly produced antibody isotype and provides the first line of immune protection at mucosal surfaces. However, IgA has long been a divisive molecule with respect to tumor progression. IgA exerts anti- or pro-tumor effect in different tumor types. In this review, we summarize emerging evidence regarding the production and effects of IgA and IgA cells in the tumor microenvironment (TME). Moreover, we discuss that the TME cytokines, host diet, microbiome, and metabolites play a pivotal role in controlling the class-switch recombination (CSR) of IgA. The analysis of intratumoral Ig repertoires and determination of metabolites that influence CSR may help establish novel therapeutic targets for the treatment of cancers.
B 细胞是体液免疫反应的主要介质，能够产生抗体。免疫球蛋白 A（IgA）是产量最丰富的抗体同种型，为黏膜表面提供第一道免疫保护。然而，IgA 长期以来一直是肿瘤进展方面存在争议的分子。IgA 在不同的肿瘤类型中发挥着抗肿瘤或促肿瘤的作用。在这篇综述中，我们总结了关于肿瘤微环境（TME）中 IgA 和 IgA 细胞的产生和作用的新证据。此外，我们还讨论了 TME 中的细胞因子、宿主饮食、微生物组和代谢物在控制 IgA 的类别转换重组（CSR）中起着关键作用。分析肿瘤内 Ig 库和确定影响 CSR 的代谢物可能有助于为癌症治疗建立新的治疗靶点。
